BAIT
CLEC16A
Gop-1, KIAA0350
C-type lectin domain family 16, member A
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
MTOR
FRAP, FRAP1, FRAP2, RAFT1, RAPT1
mechanistic target of rapamycin (serine/threonine kinase)
GO Process (30)
GO Function (9)
GO Component (11)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- TOR signaling [IMP]
- cell growth [IDA, TAS]
- cellular response to hypoxia [ISS]
- cellular response to nutrient levels [ISS]
- double-strand break repair via homologous recombination [IBA]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- growth [NAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- negative regulation of autophagy [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [IMP]
- phosphatidylinositol-mediated signaling [TAS]
- phosphorylation [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of lipid biosynthetic process [IMP]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase III promoter [IMP]
- positive regulation of translation [IDA]
- protein autophosphorylation [IDA]
- protein catabolic process [TAS]
- protein phosphorylation [IDA, IMP]
- regulation of actin cytoskeleton organization [IMP]
- response to amino acid [IDA]
- response to nutrient [NAS]
- response to stress [IMP]
- signal transduction [NAS]
Gene Ontology Molecular Function- RNA polymerase III type 1 promoter DNA binding [IDA]
- RNA polymerase III type 2 promoter DNA binding [IDA]
- RNA polymerase III type 3 promoter DNA binding [IDA]
- TFIIIC-class transcription factor binding [IDA]
- kinase activity [IDA, TAS]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein dimerization activity [IBA]
- protein serine/threonine kinase activity [IDA, TAS]
- RNA polymerase III type 1 promoter DNA binding [IDA]
- RNA polymerase III type 2 promoter DNA binding [IDA]
- RNA polymerase III type 3 promoter DNA binding [IDA]
- TFIIIC-class transcription factor binding [IDA]
- kinase activity [IDA, TAS]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein dimerization activity [IBA]
- protein serine/threonine kinase activity [IDA, TAS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.
CLEC16A is a membrane-associated C-type lectin protein that functions as a E3-ubiquitin ligase. CLEC16A regulates autophagy and mitophagy, and reportedly localizes to late endosomes. GWAS studies have associated CLEC16A SNPs to various auto-immune and neurological disorders, including multiple sclerosis and Parkinson disease. Studies in mouse models imply a role for CLEC16A in neurodegeneration. We identified bi-allelic CLEC16A truncating variants in ... [more]
Hum Genet Mar. 01, 2023; 142(3);379-397 [Pubmed: 36538041]
Throughput
- Low Throughput
Curated By
- BioGRID