BAIT
PTEN
2310035O07Rik, A130070J02Rik, AI463227, B430203M17Rik, MMAC1, TEP1
phosphatase and tensin homolog
GO Process (72)
GO Function (13)
GO Component (13)
Gene Ontology Biological Process
- activation of mitotic anaphase-promoting complex activity [IMP, ISO]
- angiogenesis [IMP]
- brain morphogenesis [IMP]
- canonical Wnt signaling pathway [ISO]
- cardiac muscle tissue development [IMP]
- cell migration [IMP]
- central nervous system development [IMP]
- central nervous system myelin maintenance [IMP]
- central nervous system neuron axonogenesis [IMP]
- dendritic spine morphogenesis [IMP]
- dentate gyrus development [IMP]
- dephosphorylation [IDA]
- endothelial cell migration [IMP]
- forebrain morphogenesis [IMP]
- heart development [IMP]
- inositol phosphate dephosphorylation [ISO]
- learning or memory [IMP]
- locomotor rhythm [IMP]
- locomotory behavior [IMP]
- long term synaptic depression [ISO]
- long-term synaptic potentiation [IMP]
- male mating behavior [IMP]
- maternal behavior [IMP]
- memory [ISO]
- multicellular organismal response to stress [IMP]
- negative regulation of G1/S transition of mitotic cell cycle [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of axonogenesis [IMP]
- negative regulation of cell aging [IMP]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [IGI, IMP, ISO]
- negative regulation of cell size [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [ISO]
- negative regulation of dendritic spine morphogenesis [IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of excitatory postsynaptic membrane potential [IMP]
- negative regulation of focal adhesion assembly [ISO]
- negative regulation of myelination [IMP]
- negative regulation of organ growth [IMP]
- negative regulation of phagocytosis [ISO]
- negative regulation of protein kinase B signaling [IMP, ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of ribosome biogenesis [IMP]
- negative regulation of synaptic vesicle clustering [IMP]
- neuron projection development [ISO]
- neuron-neuron synaptic transmission [IMP]
- peptidyl-tyrosine dephosphorylation [ISO]
- phosphatidylinositol dephosphorylation [ISO]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of apoptotic signaling pathway [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- postsynaptic density assembly [IMP]
- prepulse inhibition [IMP]
- presynaptic membrane assembly [IMP]
- prostate gland growth [IMP]
- protein dephosphorylation [ISO]
- protein kinase B signaling [IMP]
- protein stabilization [ISO]
- regulation of B cell apoptotic process [IMP]
- regulation of cell cycle [IGI]
- regulation of cellular component size [IMP]
- regulation of myeloid cell apoptotic process [IMP]
- regulation of neuron projection development [IMP]
- regulation of protein stability [ISO]
- rhythmic synaptic transmission [IMP]
- social behavior [IMP]
- synapse assembly [IMP]
- synapse maturation [IMP]
Gene Ontology Molecular Function- PDZ domain binding [ISO]
- anaphase-promoting complex binding [ISO]
- enzyme binding [ISO]
- inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [ISO]
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [IDA, ISO]
- phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [ISO]
- phosphatidylinositol-3-phosphatase activity [ISO]
- phosphoprotein phosphatase activity [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine phosphatase activity [ISO]
- protein tyrosine phosphatase activity [ISO]
- PDZ domain binding [ISO]
- anaphase-promoting complex binding [ISO]
- enzyme binding [ISO]
- inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [ISO]
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [IDA, ISO]
- phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [ISO]
- phosphatidylinositol-3-phosphatase activity [ISO]
- phosphoprotein phosphatase activity [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine phosphatase activity [ISO]
- protein tyrosine phosphatase activity [ISO]
Gene Ontology Cellular Component
- Schmidt-Lanterman incisure [IDA]
- cell projection [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic side of plasma membrane [ISO]
- dendritic spine [ISO]
- intracellular [IMP]
- mitochondrion [ISO]
- myelin sheath adaxonal region [IDA]
- neuron projection [IDA, ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- postsynaptic membrane [ISO]
Mus musculus
PREY
TGFB1
TGF-beta1, TGFbeta1, Tgfb, Tgfb-1
transforming growth factor, beta 1
GO Process (138)
GO Function (10)
GO Component (11)
Gene Ontology Biological Process
- ATP biosynthetic process [ISO]
- MAPK cascade [ISO]
- SMAD protein complex assembly [ISO]
- SMAD protein import into nucleus [ISO]
- SMAD protein signal transduction [IBA]
- T cell activation [IDA, IMP]
- T cell differentiation [IMP]
- T cell homeostasis [IMP]
- adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [IDA]
- branch elongation involved in mammary gland duct branching [IMP]
- cell activation [IDA]
- cell cycle arrest [ISO]
- cell proliferation [IDA, TAS]
- cell-cell junction organization [ISO]
- cellular calcium ion homeostasis [IMP]
- cellular response to dexamethasone stimulus [ISO]
- cellular response to growth factor stimulus [IDA]
- cellular response to organic cyclic compound [ISO]
- cellular response to transforming growth factor beta stimulus [IDA, ISO]
- chondrocyte differentiation [ISO]
- common-partner SMAD protein phosphorylation [ISO]
- defense response [TAS]
- defense response to fungus, incompatible interaction [ISO]
- endoderm development [IDA]
- epidermal growth factor receptor signaling pathway [ISO]
- epithelial to mesenchymal transition [ISO]
- evasion or tolerance of host defenses by virus [ISO]
- extracellular matrix assembly [IDA, ISO]
- extrinsic apoptotic signaling pathway [ISO]
- germ cell migration [IDA]
- hematopoietic progenitor cell differentiation [ISO]
- hyaluronan catabolic process [ISO]
- inflammatory response [IMP, ISO]
- lens fiber cell differentiation [IMP]
- lipopolysaccharide-mediated signaling pathway [ISO]
- lymph node development [IMP]
- mammary gland branching involved in thelarche [IMP]
- mammary gland development [IDA]
- mitotic cell cycle checkpoint [ISO]
- mononuclear cell proliferation [IMP]
- morphogenesis of a branching structure [ISO]
- myelination [ISO]
- myeloid dendritic cell differentiation [IMP]
- negative regulation of DNA replication [ISO]
- negative regulation of T cell activation [IMP]
- negative regulation of T cell proliferation [IMP]
- negative regulation of blood vessel endothelial cell migration [ISO]
- negative regulation of cell cycle [ISO]
- negative regulation of cell growth [IDA, ISO]
- negative regulation of cell proliferation [ISO, TAS]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of fat cell differentiation [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of hyaluronan biosynthetic process [ISO]
- negative regulation of immune response [ISO]
- negative regulation of macrophage cytokine production [ISO]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of myoblast differentiation [ISO]
- negative regulation of neuroblast proliferation [ISO]
- negative regulation of ossification [IDA]
- negative regulation of phagocytosis [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of release of sequestered calcium ion into cytosol [ISO]
- negative regulation of skeletal muscle tissue development [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- negative regulation of transcription, DNA-templated [ISO]
- organ morphogenesis [TAS]
- organ regeneration [ISO]
- pathway-restricted SMAD protein phosphorylation [IDA, ISO]
- phosphate-containing compound metabolic process [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of NAD+ ADP-ribosyltransferase activity [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of SMAD protein import into nucleus [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of branching involved in ureteric bud morphogenesis [ISO]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IDA, ISO]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of chemotaxis [ISO]
- positive regulation of collagen biosynthetic process [IDA, ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of epithelial to mesenchymal transition [IDA, ISO]
- positive regulation of exit from mitosis [ISO]
- positive regulation of fibroblast migration [ISO]
- positive regulation of gene expression [IDA, ISO]
- positive regulation of histone acetylation [IDA]
- positive regulation of histone deacetylation [IDA]
- positive regulation of interleukin-17 production [IDA, ISO]
- positive regulation of isotype switching to IgA isotypes [ISO]
- positive regulation of odontogenesis [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IBA, ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of protein complex assembly [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of protein import into nucleus [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein localization to nucleus [IGI]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein secretion [ISO]
- positive regulation of smooth muscle cell differentiation [ISO]
- positive regulation of superoxide anion generation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription regulatory region DNA binding [ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- protein export from nucleus [ISO]
- protein import into nucleus, translocation [ISO]
- protein kinase B signaling [ISO]
- protein phosphorylation [IDA, IGI]
- receptor catabolic process [ISO]
- regulation of DNA binding [IDA]
- regulation of MAPK cascade [IBA]
- regulation of actin cytoskeleton reorganization [IGI]
- regulation of apoptotic process [IBA]
- regulation of binding [IDA]
- regulation of branching involved in mammary gland duct morphogenesis [IGI]
- regulation of cartilage development [IDA]
- regulation of cell proliferation [IDA]
- regulation of miRNA metabolic process [ISO]
- regulation of protein import into nucleus [IDA]
- regulation of sodium ion transport [IDA]
- regulation of striated muscle tissue development [IDA]
- regulation of transforming growth factor beta receptor signaling pathway [ISO]
- regulatory T cell differentiation [IDA, IMP]
- response to cholesterol [ISO]
- response to estradiol [ISO]
- response to organic substance [ISO]
- response to progesterone [ISO]
- skeletal muscle tissue development [TAS]
- skeletal system development [TAS]
- tolerance induction to self antigen [IMP]
- transforming growth factor beta receptor signaling pathway [IDA, ISO]
- wound healing [ISO]
Gene Ontology Molecular Function- antigen binding [ISO]
- cytokine activity [IBA]
- enzyme binding [ISO]
- glycoprotein binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- transforming growth factor beta receptor binding [IPI, TAS]
- type II transforming growth factor beta receptor binding [IBA, ISO]
- antigen binding [ISO]
- cytokine activity [IBA]
- enzyme binding [ISO]
- glycoprotein binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- transforming growth factor beta receptor binding [IPI, TAS]
- type II transforming growth factor beta receptor binding [IBA, ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.
PTEN is a phosphoinositide lipid phosphatase and an important tumour suppressor protein. PTEN function is reduced or lost in around a third of all human cancers through diverse mechanisms, from gene deletion to changes in the function of proteins which regulate PTEN through direct protein binding. Here we present data from SILAC (Stable Isotope Labelling by Amino acids in Cell ... [more]
Adv Biol Regul Oct. 04, 2023; ();100989 [Pubmed: 37839992]
Throughput
- Low Throughput
Additional Notes
- SILAC proteomics in U87MG cells
Curated By
- BioGRID