BAIT
ESYT2
CHR2SYT, E-Syt2, FAM62B, tcag7.562
extended synaptotagmin-like protein 2
GO Process (0)
GO Function (7)
GO Component (5)
Gene Ontology Molecular Function
Homo sapiens
PREY
ELOVL2
SSC2
ELOVL fatty acid elongase 2
GO Process (9)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- alpha-linolenic acid metabolic process [TAS]
- cellular lipid metabolic process [TAS]
- fatty acid elongation, polyunsaturated fatty acid [IDA]
- linoleic acid metabolic process [TAS]
- long-chain fatty-acyl-CoA biosynthetic process [TAS]
- small molecule metabolic process [TAS]
- triglyceride biosynthetic process [TAS]
- unsaturated fatty acid metabolic process [TAS]
- very long-chain fatty acid biosynthetic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis.
Mitochondria interact with the ER at structurally and functionally specialized membrane contact sites known as mitochondria-ER contact sites (MERCs). Combining proximity labelling (BioID), co-immunoprecipitation, confocal microscopy and subcellular fractionation, we found that the ER resident SMP-domain protein ESYT1 was enriched at MERCs, where it forms a complex with the outer mitochondrial membrane protein SYNJ2BP. BioID analyses using ER-targeted, outer mitochondrial ... [more]
Life Sci Alliance Jan. 01, 2024; 7(1); [Pubmed: 37931956]
Throughput
- High Throughput
Additional Notes
- BioID
Curated By
- BioGRID