BAIT

BCL2L13

BCL-RAMBO, Bcl2-L-13, MIL1, CD003
BCL2-like 13 (apoptosis facilitator)
Cell Cycle - Mitotic Spindle Assembly Project
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

NETO2

BTCL2, NEOT2, UNQ1926/PRO4401
neuropilin (NRP) and tolloid (TLL)-like 2
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.

Jensen SA, Calvert AE, Volpert G, Kouri FM, Hurley LA, Luciano JP, Wu Y, Chalastanis A, Futerman AH, Stegh AH

Therapy resistance is a major limitation to the successful treatment of cancer. Here, we identify Bcl2-like 13 (Bcl2L13), an atypical member of the Bcl-2 family, as a therapy susceptibility gene with elevated expression in solid and blood cancers, including glioblastoma (GBM). We demonstrate that mitochondria-associated Bcl2L13 inhibits apoptosis induced by a wide spectrum of chemo- and targeted therapies upstream of ... [more]

Proc Natl Acad Sci U S A Apr. 15, 2014; 111(15);5682-7 [Pubmed: 24706805]

Throughput

  • Low Throughput

Curated By

  • BioGRID