BAIT

ANLN

FSGS8, Scraps, scra

anillin, actin binding protein

Cell Cycle - Mitotic Spindle Assembly Project

GO Process (3)

GO Function (1)

GO Component (4)

Gene Ontology Biological Process

mitotic cytokinesis [IDA]

regulation of exit from mitosis [TAS]

septin ring assembly [TAS]

Gene Ontology Molecular Function

actin binding [IDA]

Gene Ontology Cellular Component

actin cytoskeleton [IDA]

actomyosin contractile ring [IDA]

intracellular membrane-bounded organelle [IDA]

nucleoplasm [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

DDX1

DBP-RB, UKVH5d

DEAD (Asp-Glu-Ala-Asp) box helicase 1

GO Process (8)

GO Function (9)

GO Component (8)

Gene Ontology Biological Process

ATP catabolic process [IDA]

DNA duplex unwinding [IDA]

double-strand break repair [IDA]

multicellular organismal development [IEP]

nucleic acid phosphodiester bond hydrolysis [IDA]

regulation of translational initiation [NAS]

spliceosomal complex assembly [NAS]

tRNA splicing, via endonucleolytic cleavage and ligation [IMP]

Gene Ontology Molecular Function

ATP-dependent helicase activity [IDA]
DNA/RNA helicase activity [IDA]
RNA helicase activity [TAS]
chromatin binding [IDA]
nuclease activity [IDA]
poly(A) RNA binding [IDA]
poly(A) binding [IDA]
protein binding [IPI]
transcription cofactor activity [IDA]

Gene Ontology Cellular Component

cleavage body [IDA]

cytoplasm [IDA]

cytoplasmic stress granule [IDA]

nucleoplasm [IDA]

ribonucleoprotein complex [IDA]

tRNA-splicing ligase complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

Cao YF, Xie L, Tong BB, Chu MY, Shi WQ, Li X, He JZ, Wang SH, Wu ZY, Deng DX, Zheng YQ, Li ZM, Xu XE, Liao LD, Cheng YW, Li LY, Xu LY, Li EM

Anillin (ANLN) is a mitosis-related protein that promotes contractile ring formation and cytokinesis, but its cell cycle-dependent degradation mechanisms in cancer cells remain unclear. Here, we show that high expression of ANLN promotes cytokinesis and proliferation in esophageal squamous cell carcinoma (ESCC) cells and is associated with poor prognosis in ESCC patients. Furthermore, the findings of the study showed that ... [more]

Cell Death Differ Feb. 01, 2023; 30(2);527-543 [Pubmed: 36526897]

Throughput

High Throughput

Curated By

BioGRID