BAIT

ANLN

FSGS8, Scraps, scra

anillin, actin binding protein

Cell Cycle - Mitotic Spindle Assembly Project

GO Process (3)

GO Function (1)

GO Component (4)

Gene Ontology Biological Process

mitotic cytokinesis [IDA]

regulation of exit from mitosis [TAS]

septin ring assembly [TAS]

Gene Ontology Molecular Function

actin binding [IDA]

Gene Ontology Cellular Component

actin cytoskeleton [IDA]

actomyosin contractile ring [IDA]

intracellular membrane-bounded organelle [IDA]

nucleoplasm [IDA]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

HSPB1

CMT2F, HEL-S-102, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27

heat shock 27kDa protein 1

Alzheimer's Disease Project

GO Process (21)

GO Function (7)

GO Component (8)

Gene Ontology Biological Process

RNA metabolic process [TAS]

cellular component movement [TAS]

cellular response to vascular endothelial growth factor stimulus [IMP]

gene expression [TAS]

intracellular signal transduction [IMP]

mRNA metabolic process [TAS]

negative regulation of apoptotic process [TAS]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISS]

negative regulation of protein kinase activity [ISS]

platelet aggregation [IMP]

positive regulation of angiogenesis [IMP]

positive regulation of blood vessel endothelial cell migration [IMP]

positive regulation of endothelial cell chemotaxis [IMP]

positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [IMP]

positive regulation of interleukin-1 beta production [ISS]

positive regulation of tumor necrosis factor biosynthetic process [ISS]

regulation of I-kappaB kinase/NF-kappaB signaling [ISS]

regulation of translational initiation [TAS]

response to unfolded protein [NAS]

response to virus [IEP]

retina homeostasis [IEP]

Gene Ontology Molecular Function

identical protein binding [IPI]
poly(A) RNA binding [IDA]
protein binding [IPI]
protein kinase C binding [ISS]
protein kinase C inhibitor activity [ISS]
protein kinase binding [IPI]
ubiquitin binding [ISS]

Gene Ontology Cellular Component

cytoplasm [IDA, TAS]

cytoskeleton [TAS]

extracellular space [IDA]

extracellular vesicular exosome [IDA]

focal adhesion [IDA]

proteasome complex [ISS]

CRISPR Database OMIM HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

Cao YF, Xie L, Tong BB, Chu MY, Shi WQ, Li X, He JZ, Wang SH, Wu ZY, Deng DX, Zheng YQ, Li ZM, Xu XE, Liao LD, Cheng YW, Li LY, Xu LY, Li EM

Anillin (ANLN) is a mitosis-related protein that promotes contractile ring formation and cytokinesis, but its cell cycle-dependent degradation mechanisms in cancer cells remain unclear. Here, we show that high expression of ANLN promotes cytokinesis and proliferation in esophageal squamous cell carcinoma (ESCC) cells and is associated with poor prognosis in ESCC patients. Furthermore, the findings of the study showed that ... [more]

Cell Death Differ Feb. 01, 2023; 30(2);527-543 [Pubmed: 36526897]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
ANLN HSPB1	Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.	Capalbo L (2019)	High	-	BioGRID	-

Curated By

BioGRID