BAIT

ANLN

FSGS8, Scraps, scra

anillin, actin binding protein

Cell Cycle - Mitotic Spindle Assembly Project

GO Process (3)

GO Function (1)

GO Component (4)

Gene Ontology Biological Process

mitotic cytokinesis [IDA]

regulation of exit from mitosis [TAS]

septin ring assembly [TAS]

Gene Ontology Molecular Function

actin binding [IDA]

Gene Ontology Cellular Component

actin cytoskeleton [IDA]

actomyosin contractile ring [IDA]

intracellular membrane-bounded organelle [IDA]

nucleoplasm [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

PTPN1

PTP1B

protein tyrosine phosphatase, non-receptor type 1

Alzheimer's Disease Project

GO Process (19)

GO Function (8)

GO Component (5)

Gene Ontology Biological Process

JAK-STAT cascade involved in growth hormone signaling pathway [TAS]

actin cytoskeleton reorganization [IMP]

blood coagulation [TAS]

cytokine-mediated signaling pathway [TAS]

endoplasmic reticulum unfolded protein response [IDA]

interferon-gamma-mediated signaling pathway [TAS]

negative regulation of ERK1 and ERK2 cascade [ISS]

negative regulation of insulin receptor signaling pathway [NAS]

negative regulation of vascular endothelial growth factor receptor signaling pathway [ISS]

peptidyl-tyrosine dephosphorylation [IDA, IMP]

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [ISS]

platelet activation [TAS]

platelet-derived growth factor receptor-beta signaling pathway [IMP]

regulation of endocytosis [IDA]

regulation of hepatocyte growth factor receptor signaling pathway [IMP]

regulation of interferon-gamma-mediated signaling pathway [TAS]

regulation of signal transduction [IMP]

regulation of type I interferon-mediated signaling pathway [TAS]

type I interferon signaling pathway [TAS]

Gene Ontology Molecular Function

enzyme binding [IPI]
ephrin receptor binding [IPI]
poly(A) RNA binding [IDA]
protein binding [IPI]
protein kinase binding [IPI]
protein tyrosine phosphatase activity [IDA, TAS]
receptor tyrosine kinase binding [IPI]
zinc ion binding [IDA]

Gene Ontology Cellular Component

early endosome [IDA]

endoplasmic reticulum [IDA]

plasma membrane [IDA]

sorting endosome [ISS]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

Cao YF, Xie L, Tong BB, Chu MY, Shi WQ, Li X, He JZ, Wang SH, Wu ZY, Deng DX, Zheng YQ, Li ZM, Xu XE, Liao LD, Cheng YW, Li LY, Xu LY, Li EM

Anillin (ANLN) is a mitosis-related protein that promotes contractile ring formation and cytokinesis, but its cell cycle-dependent degradation mechanisms in cancer cells remain unclear. Here, we show that high expression of ANLN promotes cytokinesis and proliferation in esophageal squamous cell carcinoma (ESCC) cells and is associated with poor prognosis in ESCC patients. Furthermore, the findings of the study showed that ... [more]

Cell Death Differ Feb. 01, 2023; 30(2);527-543 [Pubmed: 36526897]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
ANLN PTPN1	Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.	Capalbo L (2019)	High	-	BioGRID	-

Curated By

BioGRID