BAIT

ANLN

FSGS8, Scraps, scra

anillin, actin binding protein

Cell Cycle - Mitotic Spindle Assembly Project

GO Process (3)

GO Function (1)

GO Component (4)

Gene Ontology Biological Process

mitotic cytokinesis [IDA]

regulation of exit from mitosis [TAS]

septin ring assembly [TAS]

Gene Ontology Molecular Function

actin binding [IDA]

Gene Ontology Cellular Component

actin cytoskeleton [IDA]

actomyosin contractile ring [IDA]

intracellular membrane-bounded organelle [IDA]

nucleoplasm [IDA]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

PDCD6IP

AIP1, ALIX, DRIP4, HP95

programmed cell death 6 interacting protein

GO Process (7)

GO Function (4)

GO Component (8)

Gene Ontology Biological Process

positive regulation of exosomal secretion [IMP]

positive regulation of extracellular vesicular exosome assembly [IMP]

regulation of extracellular vesicular exosome assembly [IMP]

ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [IMP]

viral budding via host ESCRT complex [IGI]

viral life cycle [TAS]

viral process [TAS]

Gene Ontology Molecular Function

calcium-dependent protein binding [IPI]
protein binding [IPI]
protein homodimerization activity [IPI]
proteinase activated receptor binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

endoplasmic reticulum exit site [IMP]

extracellular vesicular exosome [IDA]

focal adhesion [IDA]

immunological synapse [IDA]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

Cao YF, Xie L, Tong BB, Chu MY, Shi WQ, Li X, He JZ, Wang SH, Wu ZY, Deng DX, Zheng YQ, Li ZM, Xu XE, Liao LD, Cheng YW, Li LY, Xu LY, Li EM

Anillin (ANLN) is a mitosis-related protein that promotes contractile ring formation and cytokinesis, but its cell cycle-dependent degradation mechanisms in cancer cells remain unclear. Here, we show that high expression of ANLN promotes cytokinesis and proliferation in esophageal squamous cell carcinoma (ESCC) cells and is associated with poor prognosis in ESCC patients. Furthermore, the findings of the study showed that ... [more]

Cell Death Differ Feb. 01, 2023; 30(2);527-543 [Pubmed: 36526897]

Throughput

High Throughput

Curated By

BioGRID