BAIT
DYRK1A
2310043O08Rik, D16Ertd272e, D16Ertd493e, Dyrk, ENSMUSG00000074897, Gm10783, Mnbh, Mp86, mmb, RP24-424G16.1
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
GO Process (10)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- circadian rhythm [IMP]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of mRNA splicing, via spliceosome [IMP]
- peptidyl-serine phosphorylation [IDA, ISO]
- peptidyl-threonine phosphorylation [IDA]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of protein deacetylation [IDA]
- protein autophosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of alternative mRNA splicing, via spliceosome [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DROSHA
1110013A17Rik, AI874853, Etohi2, Rn3, Rnasen
drosha, ribonuclease type III
GO Process (9)
GO Function (5)
GO Component (0)
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis [ISO]
- RNA phosphodiester bond hydrolysis, endonucleolytic [IDA, ISO]
- defense response to Gram-negative bacterium [ISO]
- defense response to Gram-positive bacterium [ISO]
- miRNA metabolic process [IMP]
- pre-miRNA processing [IDA]
- primary miRNA processing [ISO]
- regulation of gene expression [IMP]
- regulation of miRNA metabolic process [IMP]
Gene Ontology Molecular Function
Mus musculus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.
Down syndrome (DS) is caused by human chromosome 21 (HSA21) trisomy. It is characterized by a poorly understood intellectual disability (ID). We studied two mouse models of DS, one with an extra copy of the <i>Dyrk1A</i> gene (189N3) and the other with an extra copy of the mouse Chr16 syntenic region (Dp(16)1Yey). RNA-seq analysis of the transcripts deregulated in the ... [more]
Life Sci Alliance Aug. 01, 2022; 5(12); [Pubmed: 35914814]
Throughput
- Low Throughput
Additional Notes
- Proximity Ligation Assay
Curated By
- BioGRID