BAIT

DSCAM

4932410A21Rik

Down syndrome cell adhesion molecule

GO Process (7)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

dendrite morphogenesis [IMP]

dendrite self-avoidance [IMP]

locomotory behavior [IMP]

negative regulation of cell adhesion [IMP]

positive regulation of axon extension involved in axon guidance [IDA, ISO]

positive regulation of phosphorylation [ISO]

post-embryonic retina morphogenesis in camera-type eye [IMP]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

growth cone [IDA]

plasma membrane [IDA]

CRISPR Database VEGA MGI Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

PREY

DLG2

A330103J02Rik, B230218P12Rik, B330007M19Rik, Dlgh2, Gm1197, PSD93, mCG_22690

discs, large homolog 2 (Drosophila)

GO Process (8)

GO Function (8)

GO Component (10)

Gene Ontology Biological Process

negative regulation of phosphatase activity [ISO]

nervous system development [IBA]

neuronal ion channel clustering [ISO]

nucleotide phosphorylation [IBA]

receptor clustering [IBA, ISO]

receptor localization to synapse [IBA]

sensory perception of pain [IMP]

synaptic transmission [IMP]

Gene Ontology Molecular Function

PDZ domain binding [ISO]
guanylate kinase activity [IBA]
ionotropic glutamate receptor binding [IBA]
kinase binding [ISO]
protein C-terminus binding [ISO]
protein binding [IPI]
protein heterodimerization activity [ISO]
protein phosphatase binding [ISO]

Gene Ontology Cellular Component

cell junction [IDA]

cytoplasm [ISO]

ionotropic glutamate receptor complex [IBA]

juxtaparanode region of axon [IDA, ISO]

neuronal cell body [ISO]

neuronal postsynaptic density [IDA]

postsynaptic membrane [IDA]

voltage-gated potassium channel complex [ISO]

CRISPR Database MGI Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Mus musculus

Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

Viard J, Loe-Mie Y, Daudin R, Khelfaoui M, Plancon C, Boland A, Tejedor F, Huganir RL, Kim E, Kinoshita M, Liu G, Haucke V, Moncion T, Yu E, Hindie V, Blehaut H, Mircher C, Herault Y, Deleuze JF, Rain JC, Simonneau M, Lepagnol-Bestel AM

Down syndrome (DS) is caused by human chromosome 21 (HSA21) trisomy. It is characterized by a poorly understood intellectual disability (ID). We studied two mouse models of DS, one with an extra copy of the <i>Dyrk1A</i> gene (189N3) and the other with an extra copy of the mouse Chr16 syntenic region (Dp(16)1Yey). RNA-seq analysis of the transcripts deregulated in the ... [more]

Life Sci Alliance Aug. 01, 2022; 5(12); [Pubmed: 35914814]

Throughput

Low Throughput

Additional Notes

Proximity Ligation Assay

Curated By

BioGRID