BAIT

AIRE

AIRE1, APECED, APS1, APSI, PGA1

autoimmune regulator

GO Process (4)

GO Function (7)

GO Component (1)

Gene Ontology Biological Process

immune response [TAS]

positive regulation of transcription from RNA polymerase II promoter [IMP]

positive regulation of transcription, DNA-templated [IDA]

regulation of transcription, DNA-templated [IDA]

Gene Ontology Molecular Function

RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
chromatin binding [IDA]
histone binding [IDA]
protein binding [IPI]
transcription regulatory region DNA binding [IDA]
zinc ion binding [IDA]

Gene Ontology Cellular Component

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

ATP5A1

ATP5A, ATP5AL2, ATPM, COXPD22, HEL-S-123m, MC5DN4, MOM2, OMR, ORM, hATP1

ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle

GO Process (9)

GO Function (7)

GO Component (8)

Gene Ontology Molecular Function

ATP binding [ISS]
ATPase activity [IDA]
MHC class I protein binding [IDA]
poly(A) RNA binding [IDA]
protein binding [IPI]
proton-transporting ATP synthase activity, rotational mechanism [ISS]
transmembrane transporter activity [IC]

Gene Ontology Cellular Component

COP9 signalosome [IDA]

extracellular vesicular exosome [IDA]

mitochondrial inner membrane [IDA]

mitochondrial matrix [TAS]

mitochondrial proton-transporting ATP synthase complex [IDA]

mitochondrion [IDA, NAS]

plasma membrane [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

Viard J, Loe-Mie Y, Daudin R, Khelfaoui M, Plancon C, Boland A, Tejedor F, Huganir RL, Kim E, Kinoshita M, Liu G, Haucke V, Moncion T, Yu E, Hindie V, Blehaut H, Mircher C, Herault Y, Deleuze JF, Rain JC, Simonneau M, Lepagnol-Bestel AM

Down syndrome (DS) is caused by human chromosome 21 (HSA21) trisomy. It is characterized by a poorly understood intellectual disability (ID). We studied two mouse models of DS, one with an extra copy of the <i>Dyrk1A</i> gene (189N3) and the other with an extra copy of the mouse Chr16 syntenic region (Dp(16)1Yey). RNA-seq analysis of the transcripts deregulated in the ... [more]

Life Sci Alliance Aug. 01, 2022; 5(12); [Pubmed: 35914814]

Throughput

High Throughput

Curated By

BioGRID