BAIT
APP
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
amyloid beta (A4) precursor protein
GO Process (29)
GO Function (8)
GO Component (21)
Gene Ontology Biological Process
- adult locomotory behavior [ISS]
- axon cargo transport [ISS]
- axon midline choice point recognition [ISS]
- axonogenesis [ISS]
- blood coagulation [TAS]
- cellular copper ion homeostasis [ISS]
- collateral sprouting in absence of injury [ISS]
- dendrite development [ISS]
- endocytosis [ISS]
- extracellular matrix organization [ISS, TAS]
- innate immune response [TAS]
- ionotropic glutamate receptor signaling pathway [ISS]
- locomotory behavior [ISS]
- mRNA polyadenylation [ISS]
- mating behavior [ISS]
- negative regulation of endopeptidase activity [IDA]
- neuron apoptotic process [IMP]
- neuron projection development [ISS]
- neuron remodeling [ISS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of mitotic cell cycle [ISS]
- protein phosphorylation [ISS]
- regulation of epidermal growth factor-activated receptor activity [ISS]
- regulation of multicellular organism growth [ISS]
- regulation of synapse structure or activity [ISS]
- regulation of translation [ISS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISS]
- axon [ISS]
- cell surface [IDA]
- cytoplasm [IDA, ISS]
- cytosol [TAS]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- endosome [IDA]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of membrane [ISS]
- integral component of plasma membrane [TAS]
- intracellular membrane-bounded organelle [IDA]
- membrane raft [IDA]
- nuclear envelope lumen [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- platelet alpha granule lumen [TAS]
- receptor complex [IDA]
- synapse [IDA]
Homo sapiens
PREY
LDLRAP1
ARH, ARH1, ARH2, FHCB1, FHCB2, RP11-70P17.2
low density lipoprotein receptor adaptor protein 1
GO Process (12)
GO Function (10)
GO Component (9)
Gene Ontology Biological Process
- amyloid precursor protein metabolic process [IMP]
- cholesterol homeostasis [IMP]
- cholesterol metabolic process [NAS]
- positive regulation of cholesterol metabolic process [IC]
- positive regulation of receptor-mediated endocytosis [IMP]
- positive regulation of signal transduction [IDA]
- receptor internalization [IMP]
- receptor-mediated endocytosis [IDA]
- receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [IMP]
- regulation of establishment of protein localization to plasma membrane [IMP]
- regulation of protein binding [IMP]
- transport [NAS]
Gene Ontology Molecular Function- AP-2 adaptor complex binding [IDA]
- beta-amyloid binding [IPI]
- clathrin adaptor activity [IDA]
- clathrin binding [IDA]
- low-density lipoprotein particle receptor binding [IPI]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- phosphotyrosine binding [IDA]
- protein binding [IPI]
- receptor signaling complex scaffold activity [IMP]
- signaling adaptor activity [IDA]
- AP-2 adaptor complex binding [IDA]
- beta-amyloid binding [IPI]
- clathrin adaptor activity [IDA]
- clathrin binding [IDA]
- low-density lipoprotein particle receptor binding [IPI]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- phosphotyrosine binding [IDA]
- protein binding [IPI]
- receptor signaling complex scaffold activity [IMP]
- signaling adaptor activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.
Down syndrome (DS) is caused by human chromosome 21 (HSA21) trisomy. It is characterized by a poorly understood intellectual disability (ID). We studied two mouse models of DS, one with an extra copy of the <i>Dyrk1A</i> gene (189N3) and the other with an extra copy of the mouse Chr16 syntenic region (Dp(16)1Yey). RNA-seq analysis of the transcripts deregulated in the ... [more]
Life Sci Alliance Aug. 01, 2022; 5(12); [Pubmed: 35914814]
Throughput
- High Throughput
Curated By
- BioGRID