BAIT

BTG3

ANA, TOB5, TOB55, TOFA

BTG family, member 3

GO Process (2)

GO Function (1)

GO Component (1)

Gene Ontology Biological Process

negative regulation of cell proliferation [TAS]

negative regulation of mitotic cell cycle [IDA]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

PAK1

PAKalpha

p21 protein (Cdc42/Rac)-activated kinase 1

Alzheimer's Disease Project

GO Process (21)

GO Function (5)

GO Component (13)

Gene Ontology Biological Process

Fc-epsilon receptor signaling pathway [TAS]

Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]

MAPK cascade [IDA]

T cell costimulation [TAS]

T cell receptor signaling pathway [TAS]

actin cytoskeleton reorganization [IDA, IMP]

axon guidance [TAS]

branching morphogenesis of an epithelial tube [IMP]

innate immune response [TAS]

mitotic cell cycle [IBA]

negative regulation of cell proliferation involved in contact inhibition [IMP]

neuron projection morphogenesis [ISS]

positive regulation of JUN kinase activity [IMP]

positive regulation of intracellular estrogen receptor signaling pathway [IDA]

positive regulation of peptidyl-serine phosphorylation [IDA]

positive regulation of protein phosphorylation [IMP]

positive regulation of stress fiber assembly [IMP]

protein autophosphorylation [IDA]

protein phosphorylation [IDA]

signal transduction by phosphorylation [IBA]

wound healing [IMP]

Gene Ontology Molecular Function

collagen binding [IPI]
protein binding [IPI]
protein kinase activity [IDA]
protein serine/threonine kinase activity [IDA, TAS]
receptor signaling protein serine/threonine kinase activity [IBA]

Gene Ontology Cellular Component

Golgi apparatus [IDA]

cell-cell junction [IDA]

cytoplasm [IDA]

filamentous actin [NAS]

intercalated disc [ISS]

nuclear membrane [ISS]

plasma membrane [IDA]

protein complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

Viard J, Loe-Mie Y, Daudin R, Khelfaoui M, Plancon C, Boland A, Tejedor F, Huganir RL, Kim E, Kinoshita M, Liu G, Haucke V, Moncion T, Yu E, Hindie V, Blehaut H, Mircher C, Herault Y, Deleuze JF, Rain JC, Simonneau M, Lepagnol-Bestel AM

Down syndrome (DS) is caused by human chromosome 21 (HSA21) trisomy. It is characterized by a poorly understood intellectual disability (ID). We studied two mouse models of DS, one with an extra copy of the <i>Dyrk1A</i> gene (189N3) and the other with an extra copy of the mouse Chr16 syntenic region (Dp(16)1Yey). RNA-seq analysis of the transcripts deregulated in the ... [more]

Life Sci Alliance Aug. 01, 2022; 5(12); [Pubmed: 35914814]

Throughput

High Throughput

Curated By

BioGRID