BAIT
LCOR
MLR2
ligand dependent nuclear receptor corepressor
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
TAF1
BA2R, CCG1, CCGS, DYT3, DYT3/TAF1, KAT4, N-TAF1, NSCL2, OF, P250, TAF(II)250, TAF2A, TAFII-250, TAFII250, XDP
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
GO Process (15)
GO Function (10)
GO Component (3)
Gene Ontology Biological Process
- DNA-templated transcription, initiation [ISS]
- RNA polymerase II transcriptional preinitiation complex assembly [ISS]
- cellular response to DNA damage stimulus [IC]
- gene expression [TAS]
- histone acetylation [IDA]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription initiation from RNA polymerase II promoter [ISS]
- protein autophosphorylation [IDA, TAS]
- transcription elongation from RNA polymerase II promoter [TAS]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- viral process [TAS]
Gene Ontology Molecular Function- TBP-class protein binding [IPI]
- histone acetyltransferase activity [IDA]
- lysine-acetylated histone binding [IDA]
- p53 binding [IPI]
- protein binding [IPI]
- protein serine/threonine kinase activity [IDA]
- sequence-specific DNA binding [ISS]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [ISS]
- TBP-class protein binding [IPI]
- histone acetyltransferase activity [IDA]
- lysine-acetylated histone binding [IDA]
- p53 binding [IPI]
- protein binding [IPI]
- protein serine/threonine kinase activity [IDA]
- sequence-specific DNA binding [ISS]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [ISS]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.
Down syndrome (DS) is caused by human chromosome 21 (HSA21) trisomy. It is characterized by a poorly understood intellectual disability (ID). We studied two mouse models of DS, one with an extra copy of the <i>Dyrk1A</i> gene (189N3) and the other with an extra copy of the mouse Chr16 syntenic region (Dp(16)1Yey). RNA-seq analysis of the transcripts deregulated in the ... [more]
Life Sci Alliance Aug. 01, 2022; 5(12); [Pubmed: 35914814]
Throughput
- High Throughput
Curated By
- BioGRID