BAIT
GRIK1
EAA3, EEA3, GLR5, GLUR5, GluK1
glutamate receptor, ionotropic, kainate 1
GO Process (9)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- central nervous system development [TAS]
- glutamate receptor signaling pathway [TAS]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IDA, TAS]
- nervous system development [TAS]
- regulation of synaptic transmission, glutamatergic [TAS]
- synaptic transmission [TAS]
- synaptic transmission, glutamatergic [IBA]
- transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SRI
CP-22, CP22, SCN, V19
sorcin
GO Process (17)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- action potential [TAS]
- intracellular sequestering of iron ion [TAS]
- muscle organ development [TAS]
- negative regulation of heart rate [IMP]
- negative regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- proteolysis [IBA]
- regulation of calcium ion transport [IMP]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of cell communication by electrical coupling [TAS]
- regulation of cell communication by electrical coupling involved in cardiac conduction [IMP]
- regulation of heart contraction [TAS]
- regulation of high voltage-gated calcium channel activity [IMP]
- regulation of relaxation of muscle [IMP]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [TAS]
- regulation of striated muscle contraction [TAS]
- signal transduction [TAS]
- transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.
Down syndrome (DS) is caused by human chromosome 21 (HSA21) trisomy. It is characterized by a poorly understood intellectual disability (ID). We studied two mouse models of DS, one with an extra copy of the <i>Dyrk1A</i> gene (189N3) and the other with an extra copy of the mouse Chr16 syntenic region (Dp(16)1Yey). RNA-seq analysis of the transcripts deregulated in the ... [more]
Life Sci Alliance Aug. 01, 2022; 5(12); [Pubmed: 35914814]
Throughput
- High Throughput
Curated By
- BioGRID