Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

Viard J, Loe-Mie Y, Daudin R, Khelfaoui M, Plancon C, Boland A, Tejedor F, Huganir RL, Kim E, Kinoshita M, Liu G, Haucke V, Moncion T, Yu E, Hindie V, Blehaut H, Mircher C, Herault Y, Deleuze JF, Rain JC, Simonneau M, Lepagnol-Bestel AM

Down syndrome (DS) is caused by human chromosome 21 (HSA21) trisomy. It is characterized by a poorly understood intellectual disability (ID). We studied two mouse models of DS, one with an extra copy of the <i>Dyrk1A</i> gene (189N3) and the other with an extra copy of the mouse Chr16 syntenic region (Dp(16)1Yey). RNA-seq analysis of the transcripts deregulated in the ... [more]

Life Sci Alliance Aug. 01, 2022; 5(12); [Pubmed: 35914814]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary

GRIK1

Gene Ontology Biological Process

Gene Ontology Molecular Function

extracellular-glutamate-gated ion channel activity [IBA]kainate selective glutamate receptor activity [IDA]

Gene Ontology Cellular Component

PTPRD

Gene Ontology Biological Process

Gene Ontology Molecular Function

cell adhesion molecule binding [ISS]protein binding [IPI]receptor binding [ISS]transmembrane receptor protein tyrosine phosphatase activity [TAS]

Gene Ontology Cellular Component

Two-hybrid

Publication

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

Throughput

Curated By

extracellular-glutamate-gated ion channel activity [IBA]
kainate selective glutamate receptor activity [IDA]

cell adhesion molecule binding [ISS]
protein binding [IPI]
receptor binding [ISS]
transmembrane receptor protein tyrosine phosphatase activity [TAS]