GRIK1
Gene Ontology Biological Process
- central nervous system development [TAS]
- glutamate receptor signaling pathway [TAS]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IDA, TAS]
- nervous system development [TAS]
- regulation of synaptic transmission, glutamatergic [TAS]
- synaptic transmission [TAS]
- synaptic transmission, glutamatergic [IBA]
- transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PICK1
Gene Ontology Biological Process
- ATP catabolic process [ISS]
- DNA methylation involved in embryo development [NAS]
- DNA methylation involved in gamete generation [TAS]
- cellular response to decreased oxygen levels [ISS]
- cellular response to glucose starvation [ISS]
- dendritic spine maintenance [ISS]
- dendritic spine organization [ISS]
- glial cell development [ISS]
- long term synaptic depression [ISS]
- monoamine transport [IDA]
- negative regulation of Arp2/3 complex-mediated actin nucleation [ISS]
- neuronal ion channel clustering [TAS]
- positive regulation of receptor internalization [ISS]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IDA]
- protein phosphorylation [ISS]
- receptor clustering [ISS]
- retrograde vesicle-mediated transport, Golgi to ER [NAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function- ATPase activity [ISS]
- Arp2/3 complex binding [ISS]
- G-protein coupled receptor binding [ISS]
- actin filament binding [ISS]
- enzyme binding [IPI]
- identical protein binding [ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein domain specific binding [ISS]
- protein kinase C binding [ISS]
- receptor binding [ISS]
- ATPase activity [ISS]
- Arp2/3 complex binding [ISS]
- G-protein coupled receptor binding [ISS]
- actin filament binding [ISS]
- enzyme binding [IPI]
- identical protein binding [ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein domain specific binding [ISS]
- protein kinase C binding [ISS]
- receptor binding [ISS]
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.
Down syndrome (DS) is caused by human chromosome 21 (HSA21) trisomy. It is characterized by a poorly understood intellectual disability (ID). We studied two mouse models of DS, one with an extra copy of the <i>Dyrk1A</i> gene (189N3) and the other with an extra copy of the mouse Chr16 syntenic region (Dp(16)1Yey). RNA-seq analysis of the transcripts deregulated in the ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GRIK1 PICK1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| GRIK1 PICK1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| GRIK1 PICK1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID