BAIT
ITSN1
ITSN, SH3D1A, SH3P17
intersectin 1 (SH3 domain protein)
GO Process (7)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of GTPase activity [NAS]
- positive regulation of apoptotic process [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- synaptic vesicle endocytosis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PDE2A
CGS-PDE, PDE2A1, PED2A4, cGSPDE
phosphodiesterase 2A, cGMP-stimulated
GO Process (22)
GO Function (9)
GO Component (9)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cAMP catabolic process [IDA, IMP]
- cAMP-mediated signaling [IMP]
- cGMP catabolic process [IDA]
- cGMP-mediated signaling [IMP]
- calcium ion transmembrane transport [TAS]
- cellular response to cGMP [IDA]
- cellular response to drug [IEP, IMP]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [IDA]
- cellular response to macrophage colony-stimulating factor stimulus [IDA]
- cellular response to mechanical stimulus [ISS]
- cellular response to transforming growth factor beta stimulus [IEP]
- establishment of endothelial barrier [ISS]
- metabolic process [IDA]
- monocyte differentiation [IEP]
- negative regulation of cAMP biosynthetic process [ISS]
- negative regulation of protein import into nucleus, translocation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of vascular permeability [IMP]
- positive regulation of inflammatory response [ISS]
- positive regulation of vascular permeability [IMP]
- protein targeting to mitochondrion [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.
Down syndrome (DS) is caused by human chromosome 21 (HSA21) trisomy. It is characterized by a poorly understood intellectual disability (ID). We studied two mouse models of DS, one with an extra copy of the <i>Dyrk1A</i> gene (189N3) and the other with an extra copy of the mouse Chr16 syntenic region (Dp(16)1Yey). RNA-seq analysis of the transcripts deregulated in the ... [more]
Life Sci Alliance Aug. 01, 2022; 5(12); [Pubmed: 35914814]
Throughput
- High Throughput
Curated By
- BioGRID