BAIT
PRMT2
HRMT1L1
protein arginine methyltransferase 2
GO Process (12)
GO Function (14)
GO Component (5)
Gene Ontology Biological Process
- developmental cell growth [ISS]
- histone arginine methylation [IBA]
- histone methylation [IDA, ISS]
- negative regulation of G1/S transition of mitotic cell cycle [ISS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [IBA]
- positive regulation of apoptotic process [IGI]
- positive regulation of transcription, DNA-templated [IDA]
- protein methylation [TAS]
- regulation of androgen receptor signaling pathway [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function- androgen receptor binding [IPI]
- estrogen receptor binding [IDA, IPI]
- histone methyltransferase activity [IDA]
- histone-arginine N-methyltransferase activity [IBA, ISS]
- peroxisome proliferator activated receptor binding [IPI]
- progesterone receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- protein-arginine N-methyltransferase activity [ISS]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- retinoic acid receptor binding [IPI]
- signal transducer activity [TAS]
- thyroid hormone receptor binding [IPI]
- transcription coactivator activity [IDA]
- androgen receptor binding [IPI]
- estrogen receptor binding [IDA, IPI]
- histone methyltransferase activity [IDA]
- histone-arginine N-methyltransferase activity [IBA, ISS]
- peroxisome proliferator activated receptor binding [IPI]
- progesterone receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- protein-arginine N-methyltransferase activity [ISS]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- retinoic acid receptor binding [IPI]
- signal transducer activity [TAS]
- thyroid hormone receptor binding [IPI]
- transcription coactivator activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
SHANK1
SPANK-1, SSTRIP, synamon
SH3 and multiple ankyrin repeat domains 1
GO Process (16)
GO Function (10)
GO Component (11)
Gene Ontology Biological Process
- adult behavior [IMP]
- associative learning [ISS]
- cytoskeletal anchoring at plasma membrane [NAS]
- dendritic spine morphogenesis [ISS]
- determination of affect [IMP]
- long-term memory [ISS]
- negative regulation of actin filament bundle assembly [ISS]
- neuromuscular process controlling balance [ISS]
- positive regulation of dendritic spine development [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- protein complex assembly [ISS]
- protein localization to synapse [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- social behavior [IMP]
- synapse maturation [ISS]
- vocalization behavior [IMP]
Gene Ontology Molecular Function- GKAP/Homer scaffold activity [ISS]
- SH3 domain binding [ISS]
- ankyrin repeat binding [ISS]
- identical protein binding [ISS]
- ionotropic glutamate receptor binding [ISS]
- protein C-terminus binding [ISS]
- protein binding [IPI]
- protein complex binding [ISS]
- scaffold protein binding [ISS]
- somatostatin receptor binding [ISS]
- GKAP/Homer scaffold activity [ISS]
- SH3 domain binding [ISS]
- ankyrin repeat binding [ISS]
- identical protein binding [ISS]
- ionotropic glutamate receptor binding [ISS]
- protein C-terminus binding [ISS]
- protein binding [IPI]
- protein complex binding [ISS]
- scaffold protein binding [ISS]
- somatostatin receptor binding [ISS]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [ISS]
- dendrite [NAS]
- dendritic spine [ISS]
- excitatory synapse [ISS]
- intracellular [NAS]
- ionotropic glutamate receptor complex [ISS]
- membrane [IDA]
- neuron projection [ISS]
- neuronal postsynaptic density [ISS]
- plasma membrane [ISS]
- postsynaptic membrane [ISS]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.
Down syndrome (DS) is caused by human chromosome 21 (HSA21) trisomy. It is characterized by a poorly understood intellectual disability (ID). We studied two mouse models of DS, one with an extra copy of the <i>Dyrk1A</i> gene (189N3) and the other with an extra copy of the mouse Chr16 syntenic region (Dp(16)1Yey). RNA-seq analysis of the transcripts deregulated in the ... [more]
Life Sci Alliance Aug. 01, 2022; 5(12); [Pubmed: 35914814]
Throughput
- High Throughput
Curated By
- BioGRID