BAIT
RIPK4
ANKK2, ANKRD3, DIK, NKRD3, PKK, PPS2, RIP4
receptor-interacting serine-threonine kinase 4
GO Process (2)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
ANK2
ANK-2, LQT4, brank-2
ankyrin 2, neuronal
GO Process (36)
GO Function (7)
GO Component (11)
Gene Ontology Biological Process
- SA node cell action potential [ISS]
- SA node cell to atrial cardiac muscle cell communication [IMP]
- T-tubule organization [ISS]
- atrial cardiac muscle cell action potential [IMP]
- atrial cardiac muscle cell to AV node cell communication [ISS]
- atrial septum development [IMP]
- axon guidance [TAS]
- cellular calcium ion homeostasis [ISS]
- cellular protein localization [IGI]
- membrane depolarization during SA node cell action potential [TAS]
- positive regulation of calcium ion transmembrane transporter activity [ISS]
- positive regulation of calcium ion transport [ISS]
- positive regulation of cation channel activity [ISS]
- positive regulation of gene expression [IGI]
- positive regulation of potassium ion transmembrane transporter activity [ISS]
- positive regulation of potassium ion transport [ISS]
- protein localization to M-band [ISS]
- protein localization to T-tubule [ISS]
- protein localization to cell surface [ISS]
- protein localization to endoplasmic reticulum [IGI]
- protein localization to organelle [IGI]
- protein localization to plasma membrane [IGI, ISS]
- protein stabilization [ISS]
- regulation of calcium ion transmembrane transporter activity [ISS]
- regulation of calcium ion transport [IGI]
- regulation of cardiac muscle cell contraction [IGI]
- regulation of cardiac muscle contraction [IMP]
- regulation of cardiac muscle contraction by calcium ion signaling [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IGI, ISS]
- regulation of heart rate [IMP]
- regulation of heart rate by cardiac conduction [IMP, ISS]
- regulation of protein stability [IC]
- regulation of release of sequestered calcium ion into cytosol [IGI]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- sarcoplasmic reticulum calcium ion transport [TAS]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.
Down syndrome (DS) is caused by human chromosome 21 (HSA21) trisomy. It is characterized by a poorly understood intellectual disability (ID). We studied two mouse models of DS, one with an extra copy of the <i>Dyrk1A</i> gene (189N3) and the other with an extra copy of the mouse Chr16 syntenic region (Dp(16)1Yey). RNA-seq analysis of the transcripts deregulated in the ... [more]
Life Sci Alliance Aug. 01, 2022; 5(12); [Pubmed: 35914814]
Throughput
- High Throughput
Curated By
- BioGRID