BAIT
RSPH1
CT79, RSP44, RSPH10A, TSA2, TSGA2
radial spoke head 1 homolog (Chlamydomonas)
GO Process (1)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Homo sapiens
PREY
RELN
LIS2, PRO1598, RL
reelin
GO Process (27)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- axon guidance [ISS]
- brain development [ISS]
- cell morphogenesis involved in differentiation [ISS]
- central nervous system development [ISS]
- cerebral cortex tangential migration [ISS]
- glial cell differentiation [ISS]
- hippocampus development [ISS]
- neuron migration [ISS]
- peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of CREB transcription factor activity [ISS]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- positive regulation of dendritic spine morphogenesis [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of long-term synaptic potentiation [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of protein kinase activity [ISS]
- positive regulation of protein tyrosine kinase activity [ISS]
- positive regulation of small GTPase mediated signal transduction [ISS]
- positive regulation of synapse maturation [ISS]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- reelin-mediated signaling pathway [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of behavior [ISS]
- regulation of synaptic transmission [ISS]
- response to pain [ISS]
- spinal cord patterning [ISS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.
Down syndrome (DS) is caused by human chromosome 21 (HSA21) trisomy. It is characterized by a poorly understood intellectual disability (ID). We studied two mouse models of DS, one with an extra copy of the <i>Dyrk1A</i> gene (189N3) and the other with an extra copy of the mouse Chr16 syntenic region (Dp(16)1Yey). RNA-seq analysis of the transcripts deregulated in the ... [more]
Life Sci Alliance Aug. 01, 2022; 5(12); [Pubmed: 35914814]
Throughput
- High Throughput
Curated By
- BioGRID