BAIT
TTC3
DCRR1, RNF105, TPRDIII
tetratricopeptide repeat domain 3
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BLOC1S2
BLOS2, CEAP, CEAP11, RP11-316M21.4
biogenesis of lysosomal organelles complex-1, subunit 2
GO Process (11)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- anterograde axon cargo transport [ISS]
- anterograde synaptic vesicle transport [ISS]
- extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- melanosome organization [NAS]
- microtubule nucleation [NAS]
- mitochondrial outer membrane permeabilization [IDA]
- neuron projection development [ISS]
- platelet dense granule organization [NAS]
- positive regulation of cell proliferation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IBA]
- positive regulation of transcription, DNA-templated [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.
Down syndrome (DS) is caused by human chromosome 21 (HSA21) trisomy. It is characterized by a poorly understood intellectual disability (ID). We studied two mouse models of DS, one with an extra copy of the <i>Dyrk1A</i> gene (189N3) and the other with an extra copy of the mouse Chr16 syntenic region (Dp(16)1Yey). RNA-seq analysis of the transcripts deregulated in the ... [more]
Life Sci Alliance Aug. 01, 2022; 5(12); [Pubmed: 35914814]
Throughput
- High Throughput
Curated By
- BioGRID