SIK1
Gene Ontology Biological Process
- cardiac muscle cell differentiation [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- intracellular signal transduction [IDA, ISS]
- negative regulation of CREB transcription factor activity [ISS]
- negative regulation of gluconeogenesis [ISS]
- negative regulation of triglyceride biosynthetic process [ISS]
- positive regulation of anoikis [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA, ISS]
- regulation of cell differentiation [ISS]
- regulation of mitotic cell cycle [ISS]
- regulation of myotube differentiation [ISS]
- regulation of sodium ion transport [ISS]
Gene Ontology Molecular Function
YWHAH
Gene Ontology Biological Process
- apoptotic process [TAS]
- glucocorticoid catabolic process [IDA]
- glucocorticoid receptor signaling pathway [IDA]
- intracellular protein transport [ISS]
- intrinsic apoptotic signaling pathway [TAS]
- membrane depolarization during action potential [IDA]
- membrane organization [TAS]
- negative regulation of dendrite morphogenesis [ISS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of neuron differentiation [ISS]
- regulation of sodium ion transmembrane transporter activity [IDA]
- regulation of sodium ion transport [IDA]
- regulation of synaptic plasticity [ISS]
- substantia nigra development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
AKT Blocks SIK1-Mediated Repression of STAT3 to Promote Breast Tumorigenesis.
The PI3K-AKT signaling pathway is frequently dysregulated in cancer, and it is hyperactivated in approximately 50% of breast cancers. Although inhibitors directly targeting the PI3K-AKT axis have been developed, clinical efficacy has been limited to only a subset of patients. Identification of mechanisms underlying AKT-driven tumorigenesis could lead to alternative approaches to block pathway signaling and suppress breast tumor growth. ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SIK1 YWHAH | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 319.6 | BioGRID | 3482968 | |
| YWHAH SIK1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID