BAIT
EYA4
CMD1J, DFNA10, RP11-704J17.4
EYA transcriptional coactivator and phosphatase 4
GO Process (2)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
SFPQ
POMP100, PPP1R140, PSF
splicing factor proline/glutamine-rich
GO Process (9)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- RNA splicing [TAS]
- alternative mRNA splicing, via spliceosome [IMP]
- histone H3 deacetylation [ISS]
- mRNA processing [TAS]
- negative regulation of circadian rhythm [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IDA]
- regulation of circadian rhythm [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.
The Eyes Absent proteins (EYA1-4) are a biochemically unique group of tyrosine phosphatases known to be tumour-promoting across a range of cancer types. To date, the targets of EYA phosphatase activity remain largely uncharacterised. Here, we identify Polo-like kinase 1 (PLK1) as an interactor and phosphatase substrate of EYA4 and EYA1, with pY445 on PLK1 being the primary target site. ... [more]
Nat Commun Feb. 15, 2024; 15(1);1385 [Pubmed: 38360978]
Throughput
- High Throughput
Additional Notes
- BioID
Curated By
- BioGRID