BAIT
YAP1
COB1, YAP, YAP2, YAP65, YKI
Yes-associated protein 1
GO Process (8)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- cell proliferation [IDA]
- cellular response to DNA damage stimulus [IDA]
- cellular response to gamma radiation [IDA]
- contact inhibition [IDA]
- gene expression [TAS]
- hippo signaling [TAS]
- negative regulation of nucleic acid-templated transcription [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
PAK2
PAK65, PAKgamma
p21 protein (Cdc42/Rac)-activated kinase 2
GO Process (24)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- T cell receptor signaling pathway [TAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- innate immune response [TAS]
- intracellular signal transduction [IBA]
- mitotic cell cycle [IBA]
- negative regulation of apoptotic process [IMP, TAS]
- negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [IDA]
- negative regulation of protein kinase activity [TAS]
- peptidyl-serine phosphorylation [IDA]
- phosphorylation [IDA]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of protein tyrosine kinase activity [IDA]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of apoptotic process [TAS]
- regulation of defense response to virus by virus [TAS]
- signal transduction [TAS]
- signal transduction by phosphorylation [IBA]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.
The activation of YAP/TAZ, a pair of paralogs of transcriptional coactivators, initiates a dysregulated transcription program, which is a key feature of human cancer cells. However, it is not fully understood how YAP/TAZ promote dysregulated transcription for tumor progression. In this study, we employed the BioID method to identify the interactome of YAP/TAZ and discovered that YAP/TAZ interact with multiple ... [more]
Cancer Lett Jan. 26, 2024; 585();216667 [Pubmed: 38280479]
Throughput
- High Throughput
Additional Notes
- BioID
- Interaction is part of the YAP interactome in total cells
Curated By
- BioGRID