BAIT
NUP214
CAIN, CAN, D9S46E, N214, p250, RP11-544A12.7
nucleoporin 214kDa
GO Process (14)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- carbohydrate metabolic process [TAS]
- cytokine-mediated signaling pathway [TAS]
- gene expression [TAS]
- glucose transport [TAS]
- hexose transport [TAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- mitotic nuclear envelope disassembly [TAS]
- protein export from nucleus [IMP]
- regulation of glucose transport [TAS]
- small molecule metabolic process [TAS]
- transmembrane transport [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TNPO1
IPO2, KPNB2, MIP, MIP1, TRN
transportin 1
GO Process (4)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure.
NUP98 and NUP214 form chimeric fusion proteins that assemble into phase-separated nuclear bodies containing CRM1, a nuclear export receptor. However, these nuclear bodies' function in controlling gene expression remains elusive. Here, we demonstrate that the nuclear bodies of NUP98::HOXA9 and SET::NUP214 promote the condensation of mixed lineage leukemia 1 (MLL1), a histone methyltransferase essential for the maintenance of HOX gene ... [more]
Cell Rep Aug. 29, 2023; 42(8);112884 [Pubmed: 37516964]
Throughput
- High Throughput
Curated By
- BioGRID