BAIT
ARRB2
ARB2, ARR2, BARR2
arrestin, beta 2
GO Process (18)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IDA, IMP]
- Notch signaling pathway [TAS]
- blood coagulation [TAS]
- cell chemotaxis [IMP]
- desensitization of G-protein coupled receptor protein signaling pathway by arrestin [IMP]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of natural killer cell mediated cytotoxicity [IMP]
- negative regulation of protein ubiquitination [IDA]
- platelet activation [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP]
- positive regulation of protein ubiquitination [IGI]
- positive regulation of receptor internalization [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein ubiquitination [IMP]
- receptor internalization [IDA]
- regulation of androgen receptor signaling pathway [IDA]
- transcription from RNA polymerase II promoter [IDA]
- transforming growth factor beta receptor signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
AGTR2
AT2, ATGR2, MRX88
angiotensin II receptor, type 2
GO Process (20)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IC]
- G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger [ISS]
- angiotensin-activated signaling pathway [IPI, TAS]
- blood vessel remodeling [TAS]
- brain development [NAS]
- cell surface receptor signaling pathway [IDA]
- extracellular negative regulation of signal transduction [TAS]
- intracellular signal transduction [ISS]
- negative regulation of blood vessel endothelial cell migration [NAS]
- negative regulation of cell growth [TAS]
- negative regulation of heart rate [ISS]
- negative regulation of neurotrophin TRK receptor signaling pathway [IMP]
- nitric oxide mediated signal transduction [IC, TAS]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of nitric oxide biosynthetic process [IC]
- positive regulation of nitric-oxide synthase activity [ISS]
- positive regulation of phosphoprotein phosphatase activity [IDA]
- positive regulation of vasodilation [IDA]
- regulation of blood pressure [TAS]
- regulation of systemic arterial blood pressure by circulatory renin-angiotensin [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
Functional Complexes of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Receptors: Expression in Adult but Not Fetal Lung Tissue.
Angiotensin-converting enzyme 2 (ACE2) is a membrane peptidase and a component of the renin-angiotensin system (RAS) that has been found in cells of all organs, including the lungs. While ACE2 has been identified as the receptor for severe acute respiratory syndrome (SARS) coronaviruses, the mechanism underlying cell entry remains unknown. Human immunodeficiency virus infects target cells via CXC chemokine receptor ... [more]
Int J Mol Sci Dec. 16, 2020; 21(24); [Pubmed: 33339432]
Throughput
- Low Throughput
Additional Notes
- BRET
Curated By
- BioGRID