BAIT
TWIST1
AA960487, M-Twist, Pde, Ska10, Ska, Twist, bHLHa38, pdt
twist basic helix-loop-helix transcription factor 1
GO Process (54)
GO Function (10)
GO Component (1)
Gene Ontology Biological Process
- aortic valve morphogenesis [IMP, ISO]
- cardiac neural crest cell development involved in outflow tract morphogenesis [IMP]
- cardiac neural crest cell migration involved in outflow tract morphogenesis [IMP]
- cell differentiation [IMP]
- cell proliferation involved in heart valve development [IMP, ISO]
- cellular response to hypoxia [IMP, ISO]
- cranial suture morphogenesis [IMP]
- embryonic camera-type eye formation [ISO]
- embryonic cranial skeleton morphogenesis [IGI, IMP, ISO]
- embryonic digit morphogenesis [IMP]
- embryonic forelimb morphogenesis [IMP]
- embryonic hindlimb morphogenesis [IMP]
- embryonic limb morphogenesis [IMP]
- embryonic skeletal system morphogenesis [IMP]
- endocardial cushion morphogenesis [IMP]
- eyelid development in camera-type eye [ISO]
- hindlimb morphogenesis [IMP]
- in utero embryonic development [IMP]
- mitral valve morphogenesis [IMP]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of cell differentiation [IDA]
- negative regulation of cellular senescence [ISO]
- negative regulation of double-strand break repair [ISO]
- negative regulation of histone acetylation [IDA]
- negative regulation of histone phosphorylation [ISO]
- negative regulation of molecular function [IDA]
- negative regulation of osteoblast differentiation [IDA, ISO]
- negative regulation of oxidative phosphorylation uncoupler activity [IDA]
- negative regulation of peroxisome proliferator activated receptor signaling pathway [IDA]
- negative regulation of phosphatidylinositol 3-kinase signaling [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of skeletal muscle tissue development [IDA]
- negative regulation of striated muscle tissue development [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of tumor necrosis factor production [IGI]
- neural tube closure [IMP]
- neuron migration [IMP]
- ossification [IMP]
- osteoblast differentiation [IMP]
- positive regulation of cell motility [IMP, ISO]
- positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation [IDA]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of epithelial to mesenchymal transition [IMP, ISO]
- positive regulation of fatty acid beta-oxidation [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of interleukin-6 secretion [ISO]
- positive regulation of monocyte chemotactic protein-1 production [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO, TAS]
- positive regulation of transcription regulatory region DNA binding [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- regulation of bone mineralization [ISO]
- transcription from RNA polymerase II promoter [ISO, TAS]
Gene Ontology Molecular Function- E-box binding [IDA, ISO, TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [TAS]
- bHLH transcription factor binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI, ISO]
- E-box binding [IDA, ISO, TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [TAS]
- bHLH transcription factor binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI, ISO]
Mus musculus
PREY
DEK
1810019E15Rik, D13H6S231E
DEK oncogene (DNA binding)
GO Process (3)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.
Protein interaction is critical molecular regulatory activity underlining cellular functions and precise cell fate choices. Using TWIST1 BioID-proximity-labeling and network propagation analyses, we discovered and characterized a TWIST-chromatin regulatory module (TWIST1-CRM) in the neural crest cells (NCC). Combinatorial perturbation of core members of TWIST1-CRM: TWIST1, CHD7, CHD8, and WHSC1 in cell models and mouse embryos revealed that loss of the ... [more]
Elife Feb. 08, 2021; 10(); [Pubmed: 33554859]
Throughput
- Low Throughput
Curated By
- BioGRID