BAIT
ANXA1
ANX1, LPC1, RP11-71A24.1
annexin A1
GO Process (12)
GO Function (8)
GO Component (11)
Gene Ontology Biological Process
- alpha-beta T cell differentiation [ISS]
- cellular component movement [TAS]
- cellular response to glucocorticoid stimulus [IDA]
- inflammatory response [TAS]
- keratinocyte differentiation [IDA]
- negative regulation of apoptotic process [TAS]
- negative regulation of interleukin-8 secretion [IMP]
- neutrophil clearance [IMP]
- neutrophil homeostasis [IMP]
- peptide cross-linking [IDA]
- positive regulation of vesicle fusion [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CDH13
CDHH, P105
cadherin 13
GO Process (24)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- Rac protein signal transduction [IMP]
- Rho protein signal transduction [IMP]
- adherens junction organization [TAS]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- endothelial cell migration [IDA]
- homophilic cell adhesion via plasma membrane adhesion molecules [IDA]
- keratinocyte proliferation [IDA]
- lamellipodium assembly [IDA]
- localization within membrane [IMP]
- low-density lipoprotein particle mediated signaling [IDA]
- negative regulation of cell adhesion [IDA]
- negative regulation of cell proliferation [IDA]
- positive regulation of calcium-mediated signaling [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of positive chemotaxis [IDA]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of endocytosis [IMP]
- regulation of epidermal growth factor receptor signaling pathway [IMP]
- sprouting angiogenesis [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
ANXA1-derived peptide for targeting PD-L1 degradation inhibits tumor immune evasion in multiple cancers.
Immune checkpoint inhibitors (ICIs) therapy targeting programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) shows promising clinical benefits. However, the relatively low response rate highlights the need to develop an alternative strategy to target PD-1/PD-L1 immune checkpoint. Our study focuses on the role and mechanism of annexin A1 (ANXA1)-derived peptide A11 degrading PD-L1 and the effect of A11 ... [more]
J Immunother Cancer Mar. 01, 2023; 11(3); [Pubmed: 37001908]
Throughput
- High Throughput
Curated By
- BioGRID