BAIT

ARID-1

CELE_Y108G3AL.7, Y108G3AL.7
ARID (AT-rich Interactive Domain-containing protein) homolog
GO Process (1)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Caenorhabditis elegans
PREY

PHB-2

CELE_T24H7.1, T24H7.1
phb-2 encodes the C. elegans ortholog of prohibitin PHB2; loss of phb-2 activity via RNAi indicates that phb-2 function is required for mitochondrial organization and morphology and for embryonic, germline, and somatic gonad development; PHB-2, along with prohibitin subunit PHB-1, forms a macromolecular complex that localizes to mitochondrial membranes; PHB-1 and PHB-2 are dependent upon one another for stability: loss of either phb-1 or phb-2 activity via RNAi results in depletion of both protein products.
Caenorhabditis elegans

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans.

Robert VJ, Caron M, Gely L, Adrait A, Pakulska V, Coute Y, Chevalier M, Riedel CG, Bedet C, Palladino F

The transcriptional co-regulator SIN3 influences gene expression through multiple interactions that include histone deacetylases. Haploinsufficiency and mutations in SIN3 are the underlying cause of Witteveen-Kolk syndrome and related intellectual disability and autism syndromes, emphasizing its key role in development. However, little is known about the diversity of its interactions and functions in developmental processes. Here, we show that loss of ... [more]

Development Nov. 01, 2023; 150(21); [Pubmed: 37818613]

Throughput

  • High Throughput

Curated By

  • BioGRID