BAIT
BACE1
ASP2, BACE, HSPC104
beta-site APP-cleaving enzyme 1
GO Process (3)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TNIP2
ABIN2, FLIP1, KLIP, RP3-474M20.1
TNFAIP3 interacting protein 2
GO Process (12)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- CD40 signaling pathway [ISS]
- cellular response to lipopolysaccharide [ISS]
- interleukin-1-mediated signaling pathway [ISS]
- negative regulation of endothelial cell apoptotic process [IDA]
- positive regulation of B cell activation [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of macrophage activation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein stabilization [ISS]
- toll-like receptor 2 signaling pathway [ISS]
- toll-like receptor 3 signaling pathway [ISS]
- toll-like receptor 9 signaling pathway [ISS]
Gene Ontology Molecular Function
Homo sapiens
Protein-RNA
An interaction is detected between and protein and an RNA in vitro.
Publication
TNIP2 inhibits amyloidogenesis by regulating the 3'UTR of BACE1: An in vitro study.
TNFAIP3-interacting protein 2 (TNIP2) is known as a negative regulator of NF-?B signaling and inhibit inflammatory response and apoptosis, and is also involved in RNA metabolism. In this study, we investigated the potential role of TNIP2 in amyloidogenesis critically associated with Alzheimer's disease (AD). We found a significant decline of TNIP2 protein level in both mouse and cell model of ... [more]
Neurosci Lett Jun. 21, 2023; 808();137265 [Pubmed: 37085111]
Throughput
- Low Throughput
Curated By
- BioGRID