BAIT

C9ORF72

ALSFTD, FTDALS
chromosome 9 open reading frame 72
Autophagy Project
GO Process (2)
GO Function (2)
GO Component (9)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

GTF2H2C

GTF2H2C_2
GTF2H2 family member C
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

Juelg J, Edbauer D, Behrends C

Hexanucleotide repeat expansions within C9orf72 are a frequent cause of amyotrophic lateral sclerosis and frontotemporal dementia. Haploinsufficiency leading to reduced C9orf72 protein contributes to disease pathogenesis. C9orf72 binds SMCR8 to form a robust complex that regulates small GTPases, lysosomal integrity, and autophagy. In contrast to this functional understanding, we know far less about the assembly and turnover of the C9orf72-SMCR8 ... [more]

EMBO Rep Aug. 03, 2023; 24(8);e55895 [Pubmed: 37317656]

Throughput

  • High Throughput|Low Throughput

Curated By

  • BioGRID