BAIT
C9ORF72
ALSFTD, FTDALS
chromosome 9 open reading frame 72
GO Process (2)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GCLM
GLCLR, RP4-561L24.2
glutamate-cysteine ligase, modifier subunit
GO Process (11)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- cellular nitrogen compound metabolic process [TAS]
- glutamate metabolic process [IDA]
- glutathione biosynthetic process [IDA, IMP, TAS]
- glutathione derivative biosynthetic process [TAS]
- positive regulation of glutamate-cysteine ligase activity [IBA]
- regulation of blood vessel size [IMP]
- response to drug [IDA]
- response to oxidative stress [IDA]
- small molecule metabolic process [TAS]
- sulfur amino acid metabolic process [TAS]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.
Hexanucleotide repeat expansions within C9orf72 are a frequent cause of amyotrophic lateral sclerosis and frontotemporal dementia. Haploinsufficiency leading to reduced C9orf72 protein contributes to disease pathogenesis. C9orf72 binds SMCR8 to form a robust complex that regulates small GTPases, lysosomal integrity, and autophagy. In contrast to this functional understanding, we know far less about the assembly and turnover of the C9orf72-SMCR8 ... [more]
EMBO Rep Aug. 03, 2023; 24(8);e55895 [Pubmed: 37317656]
Throughput
- High Throughput|Low Throughput
Curated By
- BioGRID