BAIT
ALK
CD246, NBLST3
anaplastic lymphoma receptor tyrosine kinase
GO Process (10)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- NIK/NF-kappaB signaling [TAS]
- activation of MAPK activity [TAS]
- cell proliferation [TAS]
- neuron development [TAS]
- peptidyl-tyrosine phosphorylation [IDA, TAS]
- phosphorylation [IDA, TAS]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- protein autophosphorylation [IDA, TAS]
- regulation of apoptotic process [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MBOAT7
BB1, LENG4, LPIAT, LRC4, MBOA7, OACT7, hMBOA-7, XXbac-BCX105G6.4
membrane bound O-acyltransferase domain containing 7
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Identification of APPB1 as a substrate for anaplastic lymphoma kinase.
Anaplastic lymphoma kinase (ALK) is a well-known oncogene involved in various malignancies such as anaplastic large cell lymphoma, lung cancer and neuroblastoma. Several substrates for fused ALK have been identified and their biological functions have been described. However, the lack of a comprehensive identification of ALK substrates limits our understanding of the biological roles of receptor ALK. Thus, this study ... [more]
J Biochem Aug. 08, 2024; (); [Pubmed: 39115278]
Throughput
- High Throughput
Additional Notes
- BioID
Curated By
- BioGRID