DRD2
Gene Ontology Biological Process
- adenohypophysis development [ISS]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IDA]
- adult walking behavior [ISS]
- arachidonic acid secretion [IDA]
- associative learning [ISS]
- axonogenesis [ISS]
- behavioral response to cocaine [ISS]
- behavioral response to ethanol [ISS]
- branching morphogenesis of a nerve [ISS]
- cellular calcium ion homeostasis [IC]
- cerebral cortex GABAergic interneuron migration [ISS]
- circadian regulation of gene expression [ISS]
- dopamine metabolic process [IC]
- intracellular signal transduction [IDA]
- locomotory behavior [ISS]
- negative regulation of adenylate cyclase activity [IDA]
- negative regulation of blood pressure [ISS]
- negative regulation of cell migration [ISS]
- negative regulation of cell proliferation [ISS]
- negative regulation of dopamine receptor signaling pathway [ISS]
- negative regulation of protein kinase B signaling [ISS]
- negative regulation of protein secretion [IDA]
- negative regulation of synaptic transmission, glutamatergic [ISS]
- negative regulation of voltage-gated calcium channel activity [IDA]
- neurological system process involved in regulation of systemic arterial blood pressure [ISS]
- neuron-neuron synaptic transmission [ISS]
- peristalsis [ISS]
- phosphatidylinositol metabolic process [ISS]
- phospholipase C-activating dopamine receptor signaling pathway [IGI]
- positive regulation of cytokinesis [IMP]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [IDA]
- positive regulation of dopamine uptake involved in synaptic transmission [ISS]
- positive regulation of growth hormone secretion [ISS]
- positive regulation of neuroblast proliferation [ISS]
- prepulse inhibition [ISS]
- protein localization [ISS]
- regulation of cAMP metabolic process [IDA]
- regulation of dopamine uptake involved in synaptic transmission [IC]
- regulation of heart rate [ISS]
- regulation of long-term neuronal synaptic plasticity [ISS]
- regulation of potassium ion transport [ISS]
- regulation of sodium ion transport [ISS]
- regulation of synaptic transmission, GABAergic [ISS]
- release of sequestered calcium ion into cytosol [ISS]
- response to amphetamine [ISS]
- response to cocaine [ISS]
- response to drug [ISS]
- response to histamine [IDA]
- response to light stimulus [ISS]
- response to morphine [ISS]
- sensory perception of smell [ISS]
- synapse assembly [ISS]
- temperature homeostasis [ISS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ARRB2
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IDA, IMP]
- Notch signaling pathway [TAS]
- blood coagulation [TAS]
- cell chemotaxis [IMP]
- desensitization of G-protein coupled receptor protein signaling pathway by arrestin [IMP]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of natural killer cell mediated cytotoxicity [IMP]
- negative regulation of protein ubiquitination [IDA]
- platelet activation [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP]
- positive regulation of protein ubiquitination [IGI]
- positive regulation of receptor internalization [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein ubiquitination [IMP]
- receptor internalization [IDA]
- regulation of androgen receptor signaling pathway [IDA]
- transcription from RNA polymerase II promoter [IDA]
- transforming growth factor beta receptor signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Ubiquitination of GRK2 Is Required for the ?-Arrestin-Biased Signaling Pathway of Dopamine D2 Receptors to Activate ERK Kinases.
A class-A GPCR dopamine D2 receptor (D2R) plays a critical role in the proper functioning of neuronal circuits through the downstream activation of both G-protein- and ?-arrestin-dependent signaling pathways. Understanding the signaling pathways downstream of D2R is critical for developing effective therapies with which to treat dopamine (DA)-related disorders such as Parkinson's disease and schizophrenia. Extensive studies have focused on ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DRD2 ARRB2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| ARRB2 DRD2 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 1514789 |
Curated By
- BioGRID