An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.

Publication

CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability.

Yang F, Ma Q, Huang B, Wang X, Pan X, Yu T, Ran L, Jiang S, Li H, Chen Y, Liu Y, Liang C, Ren J, Zhang Y, Wang S, Li W, Xiao B

Insulin like growth factor II mRNA binding protein 3 (IGF2BP3) is an RNA binding protein with multiple roles in regulation of gene expression at the post-transcriptional level and is implicated in tumorigenesis and progression of numerous cancers including gastric cancer (GC). Circular RNAs (circRNAs) are a diverse endogenous noncoding RNA population that have important regulatory roles in cancer. However, circRNAs that ... [more]

J Transl Med Jun. 20, 2023; 21(1);402 [Pubmed: 37340423]

Throughput

High Throughput|Low Throughput

Additional Notes

Hit is circular RNA

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
NFATC3 IGF2BP3	Protein-RNA Protein-RNA An interaction is detected between and protein and an RNA in vitro.	Yang F (2023)	Low	-	BioGRID	3754294

Curated By

BioGRID

Interaction Summary

IGF2BP3

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA binding [TAS]mRNA 3'-UTR binding [IDA]mRNA 5'-UTR binding [IDA]poly(A) RNA binding [IDA]protein binding [IPI]translation regulator activity [ISS]

Gene Ontology Cellular Component

NFATC3

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]protein binding [IPI]