E2F4
Gene Ontology Biological Process
- blood circulation [IMP]
- cell volume homeostasis [IMP]
- cilium assembly [IMP]
- epithelial cell development [IMP]
- organ morphogenesis [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- regulation of cell cycle [TAS]
- regulation of cell proliferation [IDA]
- regulation of cell size [IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IDA, IGI]
- regulation of transcription, DNA-templated [TAS]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO, TAS]
- transcription factor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO, TAS]
- transcription factor binding [ISO]
ARID1A
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [IDA]
- androgen receptor signaling pathway [ISO]
- cardiac chamber development [IMP]
- cardiac muscle cell differentiation [IMP]
- chromatin organization [IPI]
- chromatin remodeling [ISO]
- forebrain development [IMP]
- glucocorticoid receptor signaling pathway [ISO]
- intracellular estrogen receptor signaling pathway [ISO]
- maintenance of chromatin silencing [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- neural tube closure [IMP]
- nucleosome disassembly [ISO]
- optic cup formation involved in camera-type eye development [IMP]
- placenta blood vessel development [IMP]
- positive regulation of transcription, DNA-templated [ISO]
- toxin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Trim33 masks a non-transcriptional function of E2f4 in replication fork progression.
Replicative stress promotes genomic instability and tumorigenesis but also presents an effective therapeutic endpoint, rationalizing detailed analysis of pathways that control DNA replication. We show here that the transcription factor E2f4 recruits the DNA helicase Recql to facilitate progression of DNA replication forks upon drug- or oncogene-induced replicative stress. In unperturbed cells, the Trim33 ubiquitin ligase targets E2f4 for degradation, ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ARID1A E2F4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID