DYRK1A
Gene Ontology Biological Process
- circadian rhythm [ISS]
- mitotic cell cycle [TAS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [ISS]
- nervous system development [TAS]
- peptidyl-threonine phosphorylation [ISS]
- peptidyl-tyrosine phosphorylation [IDA, ISS]
- positive regulation of protein deacetylation [ISS]
- protein autophosphorylation [ISS]
- protein phosphorylation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TSC2
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- cell cycle arrest [TAS]
- endocytosis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- heart development [ISS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- insulin-like growth factor receptor signaling pathway [ISS]
- negative regulation of TOR signaling [IBA]
- negative regulation of Wnt signaling pathway [IBA]
- negative regulation of cell proliferation [ISS]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of phosphatidylinositol 3-kinase signaling [ISS]
- negative regulation of protein kinase B signaling [IBA, ISS]
- negative regulation of protein kinase activity [ISS]
- neural tube closure [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive chemotaxis [ISS]
- positive regulation of Ras GTPase activity [IBA]
- protein import into nucleus [ISS]
- protein kinase B signaling [ISS]
- protein localization [ISS]
- regulation of cell cycle [IBA]
- regulation of endocytosis [ISS]
- regulation of insulin receptor signaling pathway [ISS]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.
Autism spectrum disorders (ASDs) have been linked to genes with enriched expression in the brain, but it is unclear how these genes converge into cell-type-specific networks. We built a protein-protein interaction network for 13 ASD-associated genes in human excitatory neurons derived from induced pluripotent stem cells (iPSCs). The network contains newly reported interactions and is enriched for genetic and transcriptional ... [more]
Throughput
- High Throughput
Additional Notes
- log2 FC greater than 0 and FDR less than or equal to 0.1 as threshold for significant interactors
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DYRK1A TSC2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| DYRK1A TSC2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2633291 |
Curated By
- BioGRID