BAIT

APPBP2

APP-BP2, HS.84084, PAT1
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
Alzheimer's Disease Project
UPS Project
GO Process (3)
GO Function (2)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

ASCC3

ASC1p200, HELIC1, RNAH, RP1-121G13.4
activating signal cointegrator 1 complex subunit 3
Cell Cycle - Mitotic Spindle Assembly Project
Fanconi Anemia Project
GO Process (3)
GO Function (3)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Protein-peptide

An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.

Publication

Molecular basis for C-degron recognition by CRL2APPBP2 ubiquitin ligase.

Zhao S, Olmayev-Yaakobov D, Ru W, Li S, Chen X, Zhang J, Yao X, Koren I, Zhang K, Xu C

E3 ubiquitin ligases determine the specificity of eukaryotic protein degradation by selective binding to destabilizing protein motifs, termed degrons, in substrates for ubiquitin-mediated proteolysis. The exposed C-terminal residues of proteins can act as C-degrons that are recognized by distinct substrate receptors (SRs) as part of dedicated cullin-RING E3 ubiquitin ligase (CRL) complexes. APPBP2, an SR of Cullin 2-RING ligase (CRL2), ... [more]

Proc Natl Acad Sci U S A Oct. 24, 2023; 120(43);e2308870120 [Pubmed: 37844242]

Throughput

  • Low Throughput

Curated By

  • BioGRID