PDPK1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- T cell receptor signaling pathway [TAS]
- actin cytoskeleton organization [TAS]
- activation of protein kinase B activity [IDA]
- blood coagulation [TAS]
- calcium-mediated signaling [IMP]
- cell migration [IMP]
- cellular response to epidermal growth factor stimulus [IMP]
- cellular response to insulin stimulus [IMP]
- epidermal growth factor receptor signaling pathway [IMP, TAS]
- extrinsic apoptotic signaling pathway [IMP]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- intracellular signal transduction [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-threonine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- positive regulation of establishment of protein localization to plasma membrane [IMP]
- positive regulation of phospholipase activity [IMP]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- protein autophosphorylation [TAS]
- protein phosphorylation [IDA]
- regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AKT2
Gene Ontology Biological Process
- cellular protein modification process [TAS]
- cellular response to insulin stimulus [IMP]
- fat cell differentiation [TAS]
- insulin receptor signaling pathway [IMP, TAS]
- intracellular protein transmembrane transport [ISS]
- mammary gland epithelial cell differentiation [TAS]
- membrane organization [TAS]
- negative regulation of plasma membrane long-chain fatty acid transport [IMP]
- positive regulation of cell motility [IMP]
- positive regulation of fatty acid beta-oxidation [IMP]
- positive regulation of glucose import [IMP]
- positive regulation of glucose metabolic process [IMP]
- positive regulation of glycogen biosynthetic process [IMP]
- positive regulation of protein phosphorylation [ISS]
- positive regulation of protein targeting to membrane [ISS]
- positive regulation of vesicle fusion [ISS]
- regulation of cell cycle arrest [TAS]
- regulation of cell migration [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell cortex [ISS]
- cytosol [TAS]
- nucleus [IDA, TAS]
- plasma membrane [ISS, TAS]
- ruffle membrane [ISS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1.
The RTK/PI3K/AKT pathway plays key roles in the development and progression of many cancers, including GBM. As a regulatory molecule and a potential drug target, the oncogenic role of AKT has been substantially studied. Three isoforms of AKT have been identified, including AKT1, AKT2 and AKT3, but their individual functions in GBM remain controversial. Moreover, it is not known if ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PDPK1 AKT2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID