An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

The ubiquitin E3 ligase BFAR promotes degradation of PNPLA3.

Das A, Cheng H, Wang Y, Kinch LN, Liang G, Hong S, Hobbs HH, Cohen JC

A missense variant in patatin-like phospholipase domain-containing protein 3 [PNPLA3(I148M)] is the most impactful genetic risk factor for fatty liver disease (FLD). We previously showed that PNPLA3 is ubiquitylated and subsequently degraded by proteasomes and autophagosomes and that the PNPLA3(148M) variant interferes with this process. To define the machinery responsible for PNPLA3 turnover, we used small interfering (si)RNAs to inactivate ... [more]

Proc Natl Acad Sci U S A Feb. 06, 2024; 121(6);e2312291121 [Pubmed: 38294943]

Throughput

Low Throughput

Additional Notes

E2: UBE2D2

Curated By

BioGRID

Interaction Summary

BFAR

Gene Ontology Biological Process

Gene Ontology Molecular Function

structural molecule activity [TAS]

Gene Ontology Cellular Component