SNF1
Gene Ontology Biological Process
- cell adhesion [IMP]
- cellular response to nitrogen starvation [IDA]
- fungal-type cell wall assembly [IMP]
- invasive growth in response to glucose limitation [IMP]
- negative regulation of translation [IGI, IMP]
- positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [IMP]
- positive regulation of gluconeogenesis [IMP]
- protein phosphorylation [IDA]
- pseudohyphal growth [IMP]
- regulation of carbohydrate metabolic process [IGI, IPI]
- replicative cell aging [IGI, IMP]
- single-species surface biofilm formation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MCK1
Gene Ontology Biological Process
- ascospore formation [IMP]
- cellular response to heat [IMP]
- cellular response to salt stress [IMP]
- double-strand break repair via nonhomologous end joining [IMP]
- meiotic nuclear division [IMP]
- mitotic sister chromatid segregation [IGI, IMP]
- peptidyl-serine phosphorylation [IDA]
- protein phosphorylation [IDA]
- protein phosphorylation involved in cellular protein catabolic process [IGI, IMP]
Gene Ontology Molecular Function
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Snf1 and yeast GSK3-? activates Tda1 to suppress glucose starvation signaling.
In budding yeast, the presence of glucose, a preferred energy source, suppresses the expression of respiration-related genes through a process known as glucose repression. Conversely, under glucose starvation conditions, Snf1 phosphorylates and activates downstream factors, relieving this repression and allowing cells to adapt. Recently, the Tda1 protein kinase has been implicated in these glucose starvation responses, although its function remains ... [more]
Throughput
- Low Throughput
Ontology Terms
- protein/peptide modification (APO:0000131)
Additional Notes
- Genetic complex
- snf1/ rim11/ mck1 triple mutants have decreased phosphorylation levels of Hxk2
- tda1/rim11/mck1/ triple mutantation induces a decrease in the levels of Hxk2 phosphorylation
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MCK1 SNF1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -7.8122 | BioGRID | 215186 | |
| MCK1 SNF1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.3095 | BioGRID | 2175493 | |
| SNF1 MCK1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -7.3733 | BioGRID | 325389 |
Curated By
- BioGRID