BAIT

PWP1

IEF-SSP-9502
PWP1 homolog (S. cerevisiae)
UPS Project
GO Process (1)
GO Function (0)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens
PREY

CIT

CRIK, STK21
citron rho-interacting serine/threonine kinase
Cell Cycle - Mitotic Spindle Assembly Project
GO Process (4)
GO Function (3)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

An interactome-based framework for DDB1- and CUL4-associated factor prioritization in targeted protein degradation.

Yamanaka S, Nagaoka K, Shoya Y, Nishino K, Mikura Y, Tanaka K, Konishi K, Hasegawa Y, Hijikata A, Kosako H, Sawasaki T

The DDB1- and CUL4-associated factor (DCAF) family functions as substrate receptors within Cullin4-really interesting new gene (RING) ubiquitin ligases (CRL4s), facilitating proteasomal degradation of targeted substrates. Although CRL4-based targeted protein degradation (TPD) has emerged as a promising strategy to modulate undruggable proteins, the complex formation, substrates, and functional properties of many DCAFs remain poorly defined. In this study, using proximity ... [more]

Mol Cell Apr. 02, 2026; 86(7);1397-1416.e11 [Pubmed: 41932313]

Throughput

  • High Throughput

Additional Notes

  • Air-ID

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
CIT PWP1
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High-BioGRID
-

Curated By

  • BioGRID