BAIT

TNFRSF1A

CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60
tumor necrosis factor receptor superfamily, member 1A
Arachidonic Acid Pathway Project
Cell Cycle - Senescence Project
Human Papilloma Virus (HPV) Project
Synthetic Protein Interaction Project
Homo sapiens
PREY

SGTA

SGT, alphaSGT, hSGT
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
GO Process (0)
GO Function (1)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Reciprocal regulation of TNF receptor 1-mediated signaling and inflammatory damages by MARCH2 and USP22.

Li HF, Liu R, Ren P, Shu HB, Li S

The tumor necrosis factor (TNF) receptor 1 (TNF-R1) plays critical roles in inflammatory response and autoimmune diseases. The underlying mechanisms on posttranslational regulation of TNF-R1 and its functional significance remain enigmatic. In this study, we identified the deubiquitinase USP22 as a positive regulator of TNF-R1. USP22 is minimally associated with TNF-R1, which is markedly increased following TNF stimulation. USP22 deconjugates ... [more]

Proc Natl Acad Sci U S A Apr. 14, 2026; 123(15);e2531389123 [Pubmed: 41961857]

Throughput

  • High Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
SGTA TNFRSF1A
Two-hybrid
Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

High-BioGRID
-

Curated By

  • BioGRID