MSH2
Gene Ontology Biological Process
- DNA recombination [IMP]
- chromatin silencing at silent mating-type cassette [IGI]
- interstrand cross-link repair [IGI]
- maintenance of DNA repeat elements [IBA]
- meiotic gene conversion [IMP]
- meiotic mismatch repair [IMP]
- mismatch repair [IMP]
- mitotic recombination [IMP]
- negative regulation of reciprocal meiotic recombination [IBA]
- postreplication repair [IBA]
- removal of nonhomologous ends [IGI, IMP]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase activity [IDA]
- DNA insertion or deletion binding [IDA]
- DNA-dependent ATPase activity [IBA]
- Y-form DNA binding [IDA]
- damaged DNA binding [IBA]
- double-strand/single-strand DNA junction binding [IDA]
- four-way junction DNA binding [IDA]
- guanine/thymine mispair binding [IDA]
- heteroduplex DNA loop binding [IDA]
- single base insertion or deletion binding [IDA, IMP]
- ATP binding [IDA]
- ATPase activity [IDA]
- DNA insertion or deletion binding [IDA]
- DNA-dependent ATPase activity [IBA]
- Y-form DNA binding [IDA]
- damaged DNA binding [IBA]
- double-strand/single-strand DNA junction binding [IDA]
- four-way junction DNA binding [IDA]
- guanine/thymine mispair binding [IDA]
- heteroduplex DNA loop binding [IDA]
- single base insertion or deletion binding [IDA, IMP]
Gene Ontology Cellular Component
URA7
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
The genetic landscape of a cell.
A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles for approximately 75% of all genes in the budding yeast, Saccharomyces cerevisiae. A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, ... [more]
Quantitative Score
- -0.1805 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- A Synthetic Genetic Array (SGA) analysis was carried out to quantitatively score genetic interactions based on fitness defects that were estimated from the colony size of double versus single mutants. Genetic interactions were considered significant if they had an SGA score of epsilon > 0.08 for positive interactions and epsilon < -0.08 for negative interactions, and a p-value < 0.05.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| URA7 MSH2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1805 | BioGRID | 356405 | |
| MSH2 URA7 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1984 | BioGRID | 2180170 | |
| URA7 MSH2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 2399640 |
Curated By
- BioGRID