BAIT
POLR3H
RPC22.9, RPC8, RP3-347H13.9
polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)
GO Process (8)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- gene expression [TAS]
- innate immune response [TAS]
- nucleobase-containing compound metabolic process [IDA]
- positive regulation of type I interferon production [TAS]
- termination of RNA polymerase III transcription [TAS]
- transcription elongation from RNA polymerase III promoter [TAS]
- transcription from RNA polymerase III promoter [IDA, TAS]
- transcription initiation from RNA polymerase III promoter [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PCBP2
HNRNPE2, HNRPE2, hnRNP-E2
poly(rC) binding protein 2
GO Process (8)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- RNA splicing [TAS]
- gene expression [TAS]
- innate immune response [TAS]
- mRNA metabolic process [NAS]
- mRNA splicing, via spliceosome [TAS]
- negative regulation of defense response to virus [IMP]
- negative regulation of type I interferon production [TAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.
We have performed a survey of soluble human protein complexes containing components of the transcription and RNA processing machineries using protein affinity purification coupled to mass spectrometry. Thirty-two tagged polypeptides yielded a network of 805 high-confidence interactions. Remarkably, the network is significantly enriched in proteins that regulate the formation of protein complexes, including a number of previously uncharacterized proteins for ... [more]
Mol. Cell Jul. 20, 2007; 27(2);262-74 [Pubmed: 17643375]
Quantitative Score
- 0.926053 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- cell line: hek-293 cell (BTO:0000007)
Curated By
- BioGRID