BAIT

SMC2

condensin subunit SMC2, L000001927, YFR031C
Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; essential SMC chromosomal ATPase family member that forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for clustering of tRNA genes at the nucleolus
Saccharomyces cerevisiae (S288c)
PREY

KAR3

OSR11, L000000888, YPR141C
Minus-end-directed microtubule motor; functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate
Saccharomyces cerevisiae (S288c)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Putting the brake on FEAR: Tof2 promotes the biphasic release of Cdc14 phosphatase during mitotic exit.

Waples WG, Chahwan C, Ciechonska M, Lavoie BD

The completion of chromosome segregation during anaphase requires the hypercondensation of the approximately 1-Mb rDNA array, a reaction dependent on condensin and Cdc14 phosphatase. Using systematic genetic screens, we identified 29 novel genetic interactions with budding yeast condensin. Of these, FOB1, CSM1, LRS4, and TOF2 were required for the mitotic condensation of the tandem rDNA array localized on chromosome XII. ... [more]

Mol. Biol. Cell Jan. 01, 2009; 20(1);245-55 [Pubmed: 18923139]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: cytoskeleton morphology (APO:0000054)
  • phenotype: inviable (APO:0000112)

Curated By

  • BioGRID