TAF9
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CDC7
Gene Ontology Biological Process
- DNA replication initiation [IMP]
- double-strand break repair via break-induced replication [IMP]
- negative regulation of exit from mitosis [IPI]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of meiosis I [IGI]
- positive regulation of meiotic DNA double-strand break formation [IGI]
- premeiotic DNA replication [IMP]
- protein phosphorylation [IMP]
- regulation of chromatin silencing at telomere [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
TFIID and Spt-Ada-Gcn5-acetyltransferase functions probed by genome-wide synthetic genetic array analysis using a Saccharomyces cerevisiae taf9-ts allele.
TAF9 is a TATA-binding protein associated factor (TAF) conserved from yeast to humans and shared by two transcription coactivator complexes, TFIID and SAGA. The essentiality of the TAFs has made it difficult to ascertain their roles in TFIID and SAGA function. Here we performed a genomic synthetic genetic array analysis using a temperature-sensitive allele of TAF9 as a query. Results ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- Genetic interactions were scored as strong when growth defects were observed at both 30 and 34 degrees Celsius, and scored as conditional (heat sensitivity) when growth defects were observed at 34 degrees, but not at 30 degrees.
- Synthetic lethal interaction identified via a conventional ade2/ade3 synthetic lethal screen.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDC7 TAF9 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1462 | BioGRID | 1922836 | |
| TAF9 CDC7 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.3407 | BioGRID | 1947693 |
Curated By
- BioGRID