CLB5
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IEP, IMP]
- G2/M transition of mitotic cell cycle [IEP, IMP]
- positive regulation of DNA replication [IMP]
- positive regulation of spindle pole body separation [IGI]
- premeiotic DNA replication [IGI, IMP]
- regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- spindle assembly [IGI, IMP]
Gene Ontology Molecular Function
SWI5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Phosphorylation of the Sic1 inhibitor of B-type cyclins in Saccharomyces cerevisiae is not essential but contributes to cell cycle robustness.
In budding yeast, B-type cyclin (Clb)-dependent kinase activity is essential for S phase and mitosis. In newborn G(1) cells, Clb kinase accumulation is blocked, in part because of the Sic1 stoichiometric inhibitor. Previous results strongly suggested that G(1) cyclin-dependent Sic1 phosphorylation, and its consequent degradation, is essential for S phase. However, cells containing a precise endogenous gene replacement of SIC1 ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: viability (APO:0000111)
Additional Notes
- The synthetic lethality of the sic1 clb5 double mutant was partially suppressed by deletion of SWI5. (clb5 sic1 swi5 triple mutant)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
CLB5 SWI5 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.1738 | BioGRID | 541784 | |
CLB5 SWI5 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1943 | BioGRID | 2196161 |
Curated By
- BioGRID