BAIT

MOB2

YFL035C, YFL035C-A, L000003535, S000007658, S000002966, YFL034C-B
Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p
Saccharomyces cerevisiae (S288c)
PREY

KIC1

NRK1, putative serine/threonine protein kinase KIC1, L000001276, YHR102W
Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis
Kinome Project (Sc)
GO Process (3)
GO Function (3)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

ACE2, CBK1, and BUD4 in budding and cell separation.

Voth WP, Olsen AE, Sbia M, Freedman KH, Stillman DJ

Mutations in the RAM network genes, including CBK1, MOB2, KIC1, HYM1, and TAO3, cause defects in bud site selection, asymmetric apical growth, and mating projections. Additionally, these mutants show altered colony morphology, cell separation defects, and reduced CTS1 expression, phenotypes also seen by mutating the Ace2 transcription factor. We show that an ACE2 multicopy plasmid suppresses the latter three defects ... [more]

Eukaryotic Cell Jun. 01, 2005; 4(6);1018-28 [Pubmed: 15947194]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: colony appearance (APO:0000060)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
KIC1 MOB2
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
202859

Curated By

  • BioGRID